Clomethiazole


Generic Medicine Info
Contraindications
Acute pulmonary insufficiency; alcohol-dependent patients.
Special Precautions
Chronic pulmonary insufficiency, cardiac and respiratory disease, hepatic or renal impairment, history of drug abuse, marked personality disorder. Excessive sedation may occur and drowsiness may persist the next day. Maintain airway integrity during parenteral administration. Avoid prolonged use or use in 1st and 3rd trimester of pregnancy. Elderly, children.
Adverse Reactions
Nasal congestion and irritation; conjunctival irritation, headache. Rarely, paradoxical excitement, confusion, dependence, GI disturbances, rash, urticaria, bullous eruption, anaphylaxis, and alterations in liver enzymes.
Potentially Fatal: Respiratory depression.
Drug Interactions
Cimetidine inhibits metabolism. Sedation is enhanced by simultaneous admin of CNS depressants such as alcohol, barbiturates and antipsychotics. Diazoxide; calcium-channel blockers; clonidine; disulfiram; clozapine; diuretics; moxonidine; nabilone; nitrates; esomeprazole and omeprazole; muscle relaxants, dopaminergics; lofexidine; hydralazine; minoxidil and nitroprusside; antifungals; angiotensin II-receptor antagonist; antiepileptics; β-blockers; antibacterials.
ATC Classification
N05CM02 - clomethiazole ; Belongs to the class of other hypnotics and sedatives.
Disclaimer: This information is independently developed by CIMS based on clomethiazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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