Cloxacillin


Generic Medicine Info
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity to cloxacillin, other penicillins, or cephalosporins.
Special Precautions
Patients with asthma, blood disorders, history of seizure disorder, inflamed meninges. Patients undergoing cardiopulmonary bypass. Children. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor CBC with differential prior to initiation of treatment and weekly thereafter; periodic tests for renal (e.g. urinalysis, BUN, creatinine) and hepatic function. Monitor for signs of anaphylaxis during the 1st dose.
Adverse Reactions
Significant: Haematologic disorders (e.g. neutropenia, agranulocytosis, anaemia, thrombocytopenia), bacterial or fungal superinfection (including pseudomembranous colitis, C. difficile-associated diarrhoea). Gastrointestinal disorders: Diarrhoea, loose stools, nausea, vomiting, flatulence, epigastric distress, abdominal pain, stomatitis. General disorders and administration site conditions: Lethargy, fever. Immune system disorders: Urticaria, serum sickness-like reaction. Investigations: Increased serum ALT, AST, alkaline phosphatase. Musculoskeletal and connective tissue disorders: Twitching. Nervous system disorders: Myoclonus, seizure. Psychiatric disorders: Confusion. Renal and urinary disorders: Haematuria, proteinuria, renal insufficiency, renal tubular disease, interstitial nephritis. Respiratory, thoracic and mediastinal disorders: Laryngospasm, bronchospasm, sneezing, wheezing. Vascular disorders: Hypotension, thrombophlebitis.
Potentially Fatal: Anaphylactoid/hypersensitivity reactions.
Drug Interactions
Increased serum concentration with probenecid. May increase serum concentration of methotrexate. May interfere with the anticoagulant effect of vitamin K antagonists (e.g. warfarin). Tetracycline may diminish the effect of cloxacillin.
CIMS Class
Penicillins
ATC Classification
J01CF02 - cloxacillin ; Belongs to the class of beta-lactamase resistant penicillins. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on cloxacillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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