Cyanocobalamin


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Pernicious or macrocytic anaemia
Adult: 2,000 mcg daily.
Child: 1,000 mcg daily or every 2 wk.

Oral
Megaloblastic anaemia caused by vitamin B12 deficiency
Adult: 50-150 mcg daily.

Intramuscular
Pernicious or macrocytic anaemia
Adult: 250-1000 mcg, given on alternate days for 1-2 wk, then 250 mcg wkly until the blood count returns to normal. Maintenance doses: 1000 mcg, given every mth.
Renal impairment: Increased requirement in renal impairment.
Hepatic impairment: Increased requirement in hepatic impairment.
Administration
Should be taken on an empty stomach. Take between meals.
Action
Cyanocobalamin is vital to growth, hematopoiesis and nucleoprotein and myelin synthesis. As a hematopoietic agent, it is converted to coenzyme B12 needed in the conversion of methylmalonate to succinate and production of methionine from homocysteine, a reaction requiring folate. In the absence of folate, such metabolites cannot be formed and folate deficiency occurs. It is also involved in the maintenance of reduced sulfhydryl (SH) groups which are required by various SH-activated enzyme systems. Through such processes, cyanocobalamin participates in fat and carbohydrate metabolism as well as protein synthesis.
Absorption: Binds to intrinsic factor secreted by gastric mucosa; via the GI tract actively or by passive diffusion.
Distribution: In the blood, bound to transcobalamin II (specific B-globulin carrier protein); distributed and stored in the liver and bone marrow. Crosses the placenta and small amounts enter the breast milk.
Excretion: via bile by enterohepatic recycling; via urine (as unbound B12 and in small fraction).
CIMS Class
Vitamin B-Complex / with C
ATC Classification
B03BA01 - cyanocobalamin ; Belongs to the class of vitamin B12 (cyanocobalamin and analogues). Used in the treatment of anemia.
Disclaimer: This information is independently developed by CIMS based on cyanocobalamin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in