May be taken with or without food.
Administration
May be taken with or without food.
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Special Precautions
Patients with medical or familial history of seizure disorders. Patients who are slow or poor metabolisers of desloratadine may have an increased risk of adverse effects. Renal and hepatic impairment. Children. Pregnancy and lactation. Monitoring Parameters Obtain renal function test and LFT at baseline. Monitor for signs and symptoms of hypersensitivity reactions.
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Adverse Reactions
Significant: Increased risk of seizures (particularly in children). Very rarely, hypersensitivity reactions (e.g. anaphylaxis).
Gastrointestinal disorders: Dry mouth; diarrhoea (mainly in children <2 years).
General disorders and administration site conditions: Fatigue; fever (mainly in children <2 years).
Nervous system disorders: Headache.
Psychiatric disorders: Insomnia (mainly in children <2 years).
Respiratory, thoracic and mediastinal disorders: Pharyngitis; upper respiratory tract infection, cough (mainly in children <2 years).
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Drug Interactions
May increase plasma concentrations with ketoconazole, erythromycin, azithromycin, fluoxetine, and cimetidine.
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CIMS Class
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ATC Classification
R06AX27 - desloratadine ; Belongs to the class of other antihistamines for systemic use.
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