Dexamethasone + neomycin + polymyxin b


Concise Prescribing Info
Indications/Uses
Ocular inflammation with suspected or confirmed bacterial infection.
Dosage/Direction for Use
Adult: Ophth Per g oint or per mL susp contains dexamethasone 0.1%, neomycin sulfate equiv to neomycin 3.5 mg and polymyxin B sulfate 10,000 u. For ointment: Apply 3-4 times/day. For susp: Instill 4-6 times/day, up to hrly in severe disease.
Contraindications
Hypersensitivity. Epithelial herpes simplex keratitis (dendritic keratitis), varicella and viral diseases of the cornea and conjunctiva. Mycobacterial infection or fungal diseases of the eye. Amoeba infections or untreated purulent infections of the eye.
Special Precautions
Prolonged use may cause glaucoma, damage to the optic nerve, defects in visual acuity and fields of vision, posterior subcapsular cataract formation and increased risk of secondary ocular infections. Increased risk of perforations in diseases which can cause thinning of the cornea or sclera. Corticosteroids may mask infection or worsen existing infections in acute purulent conditions of the eye. Regular monitoring of the intraocular pressure is recommended if product is used for ≥10 days. Long term application of topical corticosteroids may also increase the risk of ocular fungal infections. Neomycin sulfate may cause cutaneous sensitisation. Pregnancy and lactation.
Adverse Reactions
Allergic sensitisations. Increased intraocular pressure and delayed wound healing. Irritation, burning, stinging, itching and dermatitis.
ATC Classification
C05AA09 - dexamethasone ; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids and anal fissures.
H02AB02 - dexamethasone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
A07AA05 - polymyxin B ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
S03AA03 - polymyxin B ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.
D10AA03 - dexamethasone ; Belongs to the class of topical corticosteroids used in the treatment of acne.
A01AB08 - neomycin ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
S01BA01 - dexamethasone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
S03AA01 - neomycin ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.
S02BA06 - dexamethasone ; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear.
R02AB01 - neomycin ; Belongs to the class of antibiotics used in throat preparations.
A01AC02 - dexamethasone ; Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth.
D07XB05 - dexamethasone ; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
J01GB05 - neomycin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.
A07AA01 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of intestinal infections.
D06AX04 - neomycin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.
B05CA09 - neomycin ; Belongs to the class of antiinfectives used as irrigating solutions.
S02AA11 - polymyxin B ; Belongs to the class of antiinfectives used in the treatment of ear infections.
S03BA01 - dexamethasone ; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations.
S02AA07 - neomycin ; Belongs to the class of antiinfectives used in the treatment of ear infections.
S01AA03 - neomycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
S01AA18 - polymyxin B ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
J01XB02 - polymyxin B ; Belongs to the class of polymyxins. Used in the systemic treatment of infections.
D07AB19 - dexamethasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
S01CB01 - dexamethasone ; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases.
R01AD03 - dexamethasone ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
Disclaimer: This information is independently developed by CIMS based on dexamethasone + neomycin + polymyxin b from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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