Generic Medicine Info
Should be taken with food. Take w/ or immediately after meals.
Hypersensitivity to anthraquinone derivatives. Inflammatory intestinal disease (e.g. ulcerative colitis, Crohn's disease), intestinal obstruction, painful abdominal syndromes of undetermined cause. Severe renal and hepatic impairment. Concomitant use with laxatives.
Special Precautions
Patient with previous episode of enterocolic disturbances (e.g. irritable bowel syndrome). Elderly. Moderate renal and mild to moderate hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Significant: Diarrhoea. Gastrointestinal disorders: Abdominal pain, flatulence. Hepatobiliary disorders: Hepatitis. Investigations: Elevated liver enzymes. Renal and urinary disorders: Dark yellow coloured urine. Skin and subcutaneous tissue disorders: Pruritus, rash, eczema.
Drug Interactions
Reduced bioavailability with aluminium hydroxide, magnesium hydroxide or calcium-based antacids. Increased risk of enterocolic events with antibiotics (e.g. amoxicillin/clavulanic acid) and/or chemotherapy. Increased risk of dehydration and hypokalaemia with diuretics. Increased risk of arrhythmia with cardiac glycosides (e.g. digitoxin, digoxin).
CIMS Class
Other Drugs Acting on Musculo-Skeletal System
ATC Classification
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
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