Diacerein


Concise Prescribing Info
Indications/Uses
Osteoarthritis.
Dosage/Direction for Use
Adult: PO Usual dose: 50 mg bid. Alternatively, 50 mg once daily with evening meal for 2-4 weeks. Dose may be increased to 100 mg/day in divided doses according to patient tolerability. Treatment duration may vary according to patient response and expected clinical outcome.
Administration
Should be taken with food. Take w/ or immediately after meals.
Contraindications
Hypersensitivity to anthraquinone derivatives. Inflammatory intestinal disease (e.g. ulcerative colitis, Crohn's disease), intestinal obstruction, painful abdominal syndromes of undetermined cause. Severe renal and hepatic impairment. Concomitant use with laxatives.
Special Precautions
Patient with previous episode of enterocolic disturbances (e.g. irritable bowel syndrome). Elderly. Moderate renal and mild to moderate hepatic impairment. Pregnancy and lactation.
Adverse Reactions
Significant: Diarrhoea. Gastrointestinal disorders: Abdominal pain, flatulence. Hepatobiliary disorders: Hepatitis. Investigations: Elevated liver enzymes. Renal and urinary disorders: Dark yellow coloured urine. Skin and subcutaneous tissue disorders: Pruritus, rash, eczema.
Drug Interactions
Reduced bioavailability with aluminium hydroxide, magnesium hydroxide or calcium-based antacids. Increased risk of enterocolic events with antibiotics (e.g. amoxicillin/clavulanic acid) and/or chemotherapy. Increased risk of dehydration and hypokalaemia with diuretics. Increased risk of arrhythmia with cardiac glycosides (e.g. digitoxin, digoxin).
ATC Classification
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
Disclaimer: This information is independently developed by CIMS based on diacerein from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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