Digoxin


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Ventricular tachycardia/fibrillation, hypertrophic obstructive cardiomyopathy, cardiac amyloidosis, constrictive pericarditis. Arrhythmias due to cardiac glycoside intoxication or accessory AV pathways (e.g. Wolff-Parkinson-White syndrome). Intermittent complete heart block or 2nd-degree AV block (especially if there is history of Stokes-Adams attacks).
Special Precautions
Patients with acute MI, heart failure, arrythmias, sinoatrial disorder, beri-beri heart disease, electrolyte imbalance (especially hypokalaemia, hypomagnesaemia, hypercalcaemia), thyroid disease, severe respiratory disease, sick sinus syndrome, malabsorption syndrome, gastrointestinal reconstructions. Renal impairment. Elderly and children. Pregnancy and lactation. Patient Counselling This drug may cause visual disturbances, if affected, do not drive or operate machinery. Monitoring Parameters Periodical tests for serum electrolytes and serum creatinine concentration. Heart rate and rhythm should be monitored along with periodic ECGs. Observe for noncardiac signs of toxicity such as confusion and depression.
Adverse Reactions
Cardiac disorders: Arrhythmias, cardiac conduction disorder, bigeminy, trigeminy, PR interval prolongation, sinus bradycardia. Eye disorders: Visual disorders (blurred or yellow vision). Gastrointestinal disorders: Diarrhoea, nausea, vomiting. Nervous system disorders: Cerebral impairment, dizziness, CNS disturbance. Skin and subcutaneous tissue disorders: Rash, urticaria.
Potentially Fatal: Digoxin toxicity.
Drug Interactions
ACE inhibitors (e.g. captopril), angiotensin receptor blockers (e.g. telmisartan), NSAIDs (e.g. indomethacin), COX-2 inhibitors, calcium channel blockers (e.g. verapamil, felodipine, tinapamil), antiarrhythmics (e.g. amiodarone, flecainide) antibiotics (e.g. erythromycin, tetracyclines), vasopressin receptor antagonist (tolvaptan, conivaptan), itraconazole, quinine, alprazolam, propantheline, nefazodone, atorvastatin, ciclosporin, epoprostenol, ritonavir, telaprevir, ranolazine, lapatinib, ticagrelor may increase digoxin levels. Antacids, bulk-laxatives, kaolin-pectin, acarbose, neomycin, penicillamine, rifampicin, some cytostatics, metoclopramide, sulfasalazine, adrenaline, salbutamol, cholestyramine, phenytoin, St. John's wort, bupropion, and supplemental enteral nutrient may decrease digoxin levels.
CIMS Class
ATC Classification
C01AA05 - digoxin ; Belongs to the class of digitalis glycosides. Used in the treatment of heart failure.
Disclaimer: This information is independently developed by CIMS based on digoxin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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