Dihydralazine


Generic Medicine Info
Contraindications
Severe tachycardia, dissecting aortic aneurysm, heart failure with high cardiac output, cor pulmonale, MI due to mechanical obstruction, idiopathic SLE and related disorders. Porphyria. 1st 2 trimesters during pregnancy.
Special Precautions
Ischaemic heart disaease, MI, cerebrovascular disorders, renal or hepatic impairment. Monitor for postural hypotension and tachycardia during initial therapy if given to patients with heart failure. Gradual withdrawal is advisable.
Adverse Reactions
Tachycardia, palpitations, angina pectoris, severe headache, GI disturbances, flushing, dizziness, nasal congestion, postural hypotension, fluid retention with oedema and wt gain, conjunctivitis, lachrymation, tremor, peripheral neuropathy with numbness and tingling of extremities, muscle cramps, hepatotoxicity, blood dyscrasias, haemolytic anaemia, difficulty in urinating, glomerulonephritis, constipation, paralytic ileus, depression, anxiety, hypersensitivity reactions, eosinophilia. A condition resembling SLE with prolonged use of large doses.
Drug Interactions
Agents with hypotensive action, diazoxide, thiazide diuretics.
CIMS Class
Other Antihypertensives
ATC Classification
C02DB01 - dihydralazine ; Belongs to the class of hydrazinophthalazine derivatives. Used in the treatment of hypertension.
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