Dinoprostone


Generic Medicine Info
Contraindications
Acute or history of pelvic inflammatory disease, vag infections or cervicitis, placenta praevia or unexplained vag bleeding, history of major uterine surgery or caesarean section, cephalopelvic disproportion, foetal malpresentation, foetal distress, grand multiparae, history of traumatic delivery, ruptured membranes. Active cardiac, pulmonary, renal or hepatic disease.
Special Precautions
Patient w/ compromised uteri, asthma, glaucoma, raised intraocular pressure, HTN or CV disease, epilepsy, gestational diabetes, hypothyroidism. Compromised cardiac, hepatic, or renal function. Monitoring Parameters Monitor foetal heart rate, uterine activity, progression of cervical dilation and effacement (gel, insert); confirmation of foetal death (supp).
Adverse Reactions
Significant: Rarely, disseminated intravascular coagulation (DIC). CV: HTN. GI: Diarrhoea, nausea, vomiting. Resp: Asthma, bronchospasm. Genitourinary: Uterine hypertonus, uterine rupture, abruptio placenta, pulmonary amniotic fluid embolism, rapid cervical dilatation, vag warmth, irritation, and pain. Musculoskeletal: Back pain. Dermatologic: Rash. Immunologic: Anaphylactoid reactions including shock. Others: Fever.
Potentially Fatal: Cardiac arrest.
Drug Interactions
Potentiates the uterotonic effect of oxytocic drugs.
ATC Classification
G02AD02 - dinoprostone ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
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