Diosmin + hesperidin


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Chronic venous insufficiency
Adult: Available preparations: Each 500 mg tab contains micronised purified flavonoid fraction (MPFF) corresponding to diosmin 450 mg and hesperidin 50 mg Each 1,000 mg tab contains MPFF corresponding to diosmin 900 mg and hesperidin 100 mg For cases of the lower limbs (e.g. heavy legs, early morning restless leg, pain): Recommended dose: 500 mg bid or 1,000 mg once daily.

Oral
Acute haemorrhoidal attack
Adult: Available preparations: Each 500 mg tab contains MPFF corresponding to diosmin 450 mg and hesperidin 50 mg Each 1,000 mg tab contains MPFF corresponding to diosmin 900 mg and hesperidin 100 mg Recommended dose: 1,000 mg tid for the 1st 4 days, followed by 1,000 mg bid for the next 3 days. Seek medical advice if symptoms do not resolve within 15 days.

Oral
Chronic haemorrhoids
Adult: Available preparations: Each 500 mg tab contains MPFF corresponding to diosmin 450 mg and hesperidin 50 mg Each 1,000 mg tab contains MPFF corresponding to diosmin 900 mg and hesperidin 100 mg Recommended dose: 1,000 mg daily.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Gastrointestinal disorders: Diarrhoea, dyspepsia, nausea, vomiting, colitis, abdominal pain, constipation. Immune system disorders: Angioedema. Metabolism and nutrition disorders: Isolated oedema. Nervous system disorders: Rarely, headache, dizziness. Skin and subcutaneous tissue disorders: Rarely, rash, pruritus, urticaria.
Drug Interactions
May increase the serum concentrations of substrates of CYP2E1 (e.g. chlorzoxazone), CYP2C9 (e.g. diclofenac Na), or P-glycoprotein (e.g. fexofenadine).
Action
Diosmin and hesperidin are venotonic and vasoprotective flavonoid compounds. The combination reduces venous distensibility and stasis, and normalises capillary permeability and reinforces capillary resistance in the microcirculation. Diosmin is synthesised from hesperidin. It acts as a phlebotonic and vascular protector for venous leg ulcers and haemorrhoids. Synonym: diosmin: diosmine.
Absorption: Diosmin: Time to peak plasma concentration: 1 hour.
Distribution: Diosmin: Volume of distribution: 54.2-70 L.
Metabolism: Diosmin: Rapidly hydrolysed in the intestine by the gut microbiome into the active metabolite, diosmetin.
Excretion: Diosmin: Via faeces (approx 50% as unchanged drug or metabolite); urine (approx 14%). Elimination half-life: 11 hours.
Storage
Oral: Store below 30°C.
ATC Classification
C05CA03 - diosmin ; Belongs to the class of bioflavonoids used as capillary stabilizing agents.
Disclaimer: This information is independently developed by CIMS based on diosmin + hesperidin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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