Dobutamine


Generic Medicine Info
Contraindications
Idiopathic hypertrophic subaortic stenosis (IHSS), phaeochromocytoma.
Special Precautions
Patient w/ hyperthyroidism, active myocardial ischaemia or recent MI, cardiogenic shock complicated by severe hypotension, DM, closed angle glaucoma. Correct hypovolaemia prior to treatment. Childn, including neonates. Pregnancy and lactation. Monitoring Parameters Monitor BP, ECG, cardiac output and pulmonary wedge pressure.
Adverse Reactions
Increased heart rate, ectopic heartbeats, angina, chest pain, palpitation, elevations in BP, skin rash, fever, eosinophilia, bronchospasm, paraesthesia, nausea, vomiting, tingling sensation, dyspnoea, fever, headache, mild leg cramps; pruritus of the scalp; phlebitis at the inj site. Rarely, ventricular tachycardia, hypokalaemia.
Drug Interactions
Risk of hypotension and tachycardia w/ α-blockers (e.g. phenoxybenzamine). May produce ventricular arrhythmias w/ cyclopropane, halothane and other halogenated anaesth. Increased risk of arrhythmias w/ quinidine and cardiac glycosides. Risk of HTN and arrhythmias w/ TCAs. May increase BP w/ antihypertensives. Risk of severe HTN and bradycardia w/ β-blocker esp non-selective β-blockers. Reduced cardiotonic effects w/ CaCl infusion. Increased risk of HTN w/ doxapram. Enhanced effects w/ entacapone. Risk of ergotism w/ ergotamine or ergometrine (ergonovine) or methysergide. Oxytocin may possibly enhance the pressor effect of dobutamine w/ or w/o HTN.
CIMS Class
Cardiac Drugs
ATC Classification
C01CA07 - dobutamine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.
Disclaimer: This information is independently developed by CIMS based on dobutamine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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