Dopamine


Generic Medicine Info
Contraindications
Phaeochromocytoma, hyperthyroidism, uncorrected tachyarrhythmias or ventricular fibrillation. Concurrent use with cyclopropane and halogenated hydrocarbon anaesthetics.
Special Precautions
Patients with CV disease, cardiac arrythmias, occlusive vascular disease (e.g. atherosclerosis, arterial embolism, Raynaud's disease, cold injury, diabetic endarteritis, Buerger's disease), active myocardial ischaemia, post-myocardial infarction, electrolyte imbalance (e.g. hypokalaemia, hypomagnesemia). Correct hypovolaemia, hypoxia, hypercapnia, acidosis and electrolyte disturbances prior to initiation of therapy. Concomitant use with MAOIs. Infuse into a large vein to prevent extravasation. Pregnancy and lactation. Monitoring Parameters Monitor blood pressure, ECG, heart rate, cardiac output, pulmonary wedge pressure, serum glucose, renal function and urine output.
Adverse Reactions
Significant: Arrythmia, extravasation. Blood and lymphatic system disorders: Azotaemia. Cardiac disorders: Anginal pain, atrial fibrillation, bradycardia, palpitation, ectopic beats, tachycardia, ventricular conduction, widened QRS complex. Gastrointestinal disorders: Nausea, vomiting. Nervous system disorders: Headache. Psychiatric disorders: Anxiety. Respiratory, thoracic and mediastinal disorders: Dyspnoea. Skin and subcutaneous tissue disorders: Piloerection. Vascular disorders: Hypertension, hypotension.
Potentially Fatal: Rarely, ventricular arrythmia, gangrene (high dose).
Drug Interactions
Cardiac effects are antagonised by β-adrenergic agents (e.g. propanolol, metoprolol). α-adrenergic blocking agents may antagonise the vasoconstricting effect of high dose dopamine. Prolonged and enhanced effect with MAOIs. Risk of hypotension and bradycardia with phenytoin. May enhance effect of diuretics. Risk of excessive vasoconstriction with ergot alkaloids. May enhance vasopressor effect with TCAs and guanethidine.
CIMS Class
Cardiac Drugs
ATC Classification
C01CA04 - dopamine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.
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