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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Reversible airways obstruction; COPD 400 mg bid-tid.
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Contraindications
Acute MI, hypotension. Lactation.
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Special Precautions
Patients with cardiac disease (e.g. cardiac arrhythmias, angina pectoris, CHF, acute myocardial injury, hypertension), peptic ulcer, hyperthyroidism, hypoxemia, chronic cor pulmonale, convulsive disorder. Hepatic and renal impairment. Children and elderly. Pregnancy.
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Adverse Reactions
Cardiac disorders: Tachycardia, palpitation, extrasystole.
Metabolism and nutrition disorders: Hyperglycaemia.
Gastrointestinal disorders: Nausea, vomiting, abdominal pain, epigastric distress.
General disorders and administration site conditions: Irritability.
Nervous system disorders: Headache, nervousness, dizziness.
Psychiatric disorders: Insomnia, nervousness.
Renal and urinary disorders: Albuminuria.
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Drug Interactions
Decreased xanthine clearance with cimetidine, allopurinol, propranolol, antibiotics (e.g. erythromycin, lincomycin, ciprofloxacin) and anti-flu vaccine. Increased xanthine clearance with anticonvulsants (e.g. phenytoin). May potentiate hypokalaemia with β-2 agonist.
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CIMS Class
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ATC Classification
R03DA11 - doxofylline ; Belongs to the class of xanthines. Used in the systemic treatment of obstructive airway diseases.
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