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Dosage/Direction for Use
Oral As an antispasmodic Adult: 40-80 mg tid. Child: 1-6 yr: 20 mg 3-4 times daily; >6 yr: 40 mg tid. |
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Administration
May be taken with or without food.
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Contraindications
Severe renal/hepatic/cardiac dysfunction. Porphyria.
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Special Precautions
Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.
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Adverse Reactions
Vertigo, nausea, vomiting, dry mouth.
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Drug Interactions
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
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Action
Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
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CIMS Class
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ATC Classification
A03AD02 - drotaverine ; Belongs to the class of papaverine and derivatives. Used in the treatment of functional bowel disorders.
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