Epoprostenol


Generic Medicine Info
Contraindications
Hypersensitivity; severe left ventricular dysfunction.
Special Precautions
Elderly, pregnancy and lactation; haemorrhagic diathesis. Avoid abrupt interruptions or sudden dosage changes as it may cause rebound pulmonary hypertension. Avoid extravasation. Anticoagulant monitoring required when given with heparin. Dose titration for pulmonary hypertension should be in hospital (risk of pulmonary oedema). Monitor haematological and CV function.
Adverse Reactions
Hypotension, bradycardia, pallor, sweating, headache, tachycardia, pulmonary oedema; flushing; GI disturbances; lassitude; jaw pain, myalgia, tremor; anxiety; nervousness; drowsiness; chest pain; dry mouth, hyperglycaemia and inj site reactions; flu-like symptoms; erythema over the infusion site.
Drug Interactions
Enhanced hypotensive effects by other vasodilators, diuretics, acetate in dialysis fluids. Increased risk of bleeding with anticoagulants and antiplatelet.
ATC Classification
B01AC09 - epoprostenol ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Disclaimer: This information is independently developed by CIMS based on epoprostenol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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