Generic Medicine Info
Hypersensitivity; severe left ventricular dysfunction.
Special Precautions
Elderly, pregnancy and lactation; haemorrhagic diathesis. Avoid abrupt interruptions or sudden dosage changes as it may cause rebound pulmonary hypertension. Avoid extravasation. Anticoagulant monitoring required when given with heparin. Dose titration for pulmonary hypertension should be in hospital (risk of pulmonary oedema). Monitor haematological and CV function.
Adverse Reactions
Hypotension, bradycardia, pallor, sweating, headache, tachycardia, pulmonary oedema; flushing; GI disturbances; lassitude; jaw pain, myalgia, tremor; anxiety; nervousness; drowsiness; chest pain; dry mouth, hyperglycaemia and inj site reactions; flu-like symptoms; erythema over the infusion site.
Drug Interactions
Enhanced hypotensive effects by other vasodilators, diuretics, acetate in dialysis fluids. Increased risk of bleeding with anticoagulants and antiplatelet.
ATC Classification
B01AC09 - epoprostenol ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
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