Full Generic Medicine Info
Dosage/Direction for Use

Menopausal hormone replacement therapy
Adult: 0.5-3 mg daily for 1 mth followed by 0.5-1 mg daily; or 0.25-2 mg daily in combination with other natural oestrogens. A progestogen is required if administered to women with a uterus.

Infertility due to cervical hostility
Adult: 0.25-1 mg/day on days 6-15 of the menstrual cycle. Increase dose each mth until an optimal effect is obtained.

Menopausal atrophic vaginitis
Adult: As 0.01% or 0.1% cream or 500 mcg pessary: Apply 500 mcg once daily, reduce to twice wkly subsequently.
May be taken with or without food.
Pregnancy, thrombosis, known or suspected oestrogen-dependent tumors, vag bleeding, history of undiagnosed manifesation of deterioration of otosclerosis during pregnancy or previous use of steroids.
Special Precautions
Thrombosis, severe liver disorders, porphyria, history during pregnancy or previous use of steroids of severe pruritus, cholestatic jaundice, herpes gestationis or otosclerosis. Lactation.
Adverse Reactions
Breast tension or pain, nausea, spotting. Fluid retention, cervical hypersecretion.
Drug Interactions
Reduced efficacy may occur when used with activated charcoal, barbiturates, carbamazepine, griseofulvin, hydantoin and rifampicin. May possibly change efficacy of oral anticoagulants and increase pharmacologic effects of succinylcholine, theophyllines and troleandromycin.
Lab Interference
Reduce responses to metyrapone test. May interfere with thyroid function and glucose tolerance tests.
Estriol is a naturally occurring oestrogen. It induces normalization of vag epithelium. It is claimed to have only a mild proliferative effect on the endometrium. It only has a short retention time in the nuclei of endometrial cells.
CIMS Class
Oestrogens & Progesterones & Related Synthetic Drugs / Preparations for Vaginal Conditions
ATC Classification
G03CA04 - estriol ; Belongs to the class of natural and semisynthetic estrogens used in estrogenic hormone preparations.
G03CC06 - estriol ; Belongs to the class of estrogens in combination with other drugs used in estrogenic hormone preparations.
Disclaimer: This information is independently developed by CIMS based on estriol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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