Ethionamide


Generic Medicine Info
Administration
Should be taken with food. Take at mealtimes.
Contraindications
Hypersensitivity to ethionamide. Severe hepatic impairment.
Special Precautions
Patient w/ depression or other psychiatric illness, DM, porphyria, thyroid dysfunction. Hepatic or renal impairment. Pregnancy and lactation. Monitoring Parameters Monitor serum ALT and AST at baseline and mthly; blood glucose and TSH periodically. Perform ophthalmologic exams prior to and during therapy. Evaluate CNS changes, ocular changes, and neuritis during therapy.
Adverse Reactions
Nervous: Psychotic disturbances, mental depression, anxiety, drowsiness, dizziness, restlessness, headache, peripheral neuritis, paraesthesia, seizures, tremors, pellagra-like syndrome, hallucination, asthenia. CV: Orthostatic hypotension. GI: Nausea, vomiting, diarrhoea, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia, wt loss. Resp: Olfactory disturbances. Hepatic: Hepatitis, transient increase in serum bilirubin, AST, ALT. Endocrine: Hypothyroidism, hypoglycaemia, gynaecomastia, impotence, menorrhagia. Haematologic: Thrombocytopenia. Musculoskeletal: Joint pain, acute rheumatic symptoms. Ophthalmologic: Diplopia, optic neuritis, blurred vision. Dermatologic: Rash, photosensitivity, purpura, acne, dermatitis, alopecia.
Drug Interactions
May potentiate AR of other anti-TB drugs. Additive CNS effect w/ isoniazid and cycloserine. May cause seizures w/ cycloserine.
CIMS Class
ATC Classification
J04AD03 - ethionamide ; Belongs to the class of thiocarbamide derivatives. Used in the systemic treatment of tuberculosis.
Disclaimer: This information is independently developed by CIMS based on ethionamide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in