Ethosuximide


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
Hypersensitivity w/ ethosuximide.
Special Precautions
Hepatic or renal impairment. Pregnancy and lactation. Patient Counselling Avoid abrupt withdrawal. May impair ability to drive or operate machinery. Monitoring Parameters Monitor seizure frequency, trough serum concentration, platelets, and signs of rash and suicidality. Monitor CBC, liver enzymes, and urinalysis periodically.
Adverse Reactions
Significant: Mental depression w/ suicidal intentions, SLE. Nervous: Drowsiness, headache, fatigue, dizziness, ataxia, irritability, euphoria, hyperactivity, lethargy, sleep disturbances, night terrors, aggressiveness, inability to concentrate, paranoid psychosis, increased libido. GI: Anorexia, wt loss, vague gastric upset, cramps, abdominal pain, diarrhoea, nausea, vomiting, epigastric distress, gum hypertrophy, swelling of the tongue. Resp: Hiccups. Genitourinary: Vag bleeding, microscopic hematuria. Ophthalmologic: Myopia. Dermatologic: Urticaria, pruritic erythematous rashes, hirsutism.
Potentially Fatal: Blood dyscrasias (e.g. leucopoenia, eosinophilia, agranulocytosis, pancytopaenia w/ or w/o bone marrow depression), aplastic anaemia, drug reaction w/ eosinophilia and systemic symptoms (DRESS), toxic epidermal necrolysis. Rarely, Stevens-Johnson syndrome.
Drug Interactions
Increased plasma concentration and risk of toxicity w/ isoniazid, valproic acid. Antagonised effect w/ antidepressants, antipsychotics. Decreased plasma concentration w/ carbamazepine, phenobarbital, phenytoin.
CIMS Class
ATC Classification
N03AD01 - ethosuximide ; Belongs to the class of succinimide derivatives antiepileptics.
Disclaimer: This information is independently developed by CIMS based on ethosuximide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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