Ethosuximide


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Absence seizures
Adult: Initially, 500 mg daily in 2 divided doses, may increase in increments of 250 mg at 4-7 days interval. Usual dose: 1-1.5 g daily in 2 divided doses. Max: up to 2 g daily.
Child: <6 yr Initially, 250 mg daily, may increase gradually in small increments every few days to a usual dose of 20 mg/kg daily. Max: 1 g daily; ≥6 yr Same as adult dose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity w/ ethosuximide.
Special Precautions
Hepatic or renal impairment. Pregnancy and lactation. Patient Counselling Avoid abrupt withdrawal. May impair ability to drive or operate machinery. Monitoring Parameters Monitor seizure frequency, trough serum concentration, platelets, and signs of rash and suicidality. Monitor CBC, liver enzymes, and urinalysis periodically.
Adverse Reactions
Significant: Mental depression w/ suicidal intentions, SLE. Nervous: Drowsiness, headache, fatigue, dizziness, ataxia, irritability, euphoria, hyperactivity, lethargy, sleep disturbances, night terrors, aggressiveness, inability to concentrate, paranoid psychosis, increased libido. GI: Anorexia, wt loss, vague gastric upset, cramps, abdominal pain, diarrhoea, nausea, vomiting, epigastric distress, gum hypertrophy, swelling of the tongue. Resp: Hiccups. Genitourinary: Vag bleeding, microscopic hematuria. Ophthalmologic: Myopia. Dermatologic: Urticaria, pruritic erythematous rashes, hirsutism.
Potentially Fatal: Blood dyscrasias (e.g. leucopoenia, eosinophilia, agranulocytosis, pancytopaenia w/ or w/o bone marrow depression), aplastic anaemia, drug reaction w/ eosinophilia and systemic symptoms (DRESS), toxic epidermal necrolysis. Rarely, Stevens-Johnson syndrome.
Overdosage
Symptoms: Nausea, vomiting, CNS depression (e.g. coma w/ resp depression). Management: Symptomatic and supportive treatment. Induce emesis, perform gastric lavage, or administer activated charcoal and purgatives.
Drug Interactions
Increased plasma concentration and risk of toxicity w/ isoniazid, valproic acid. Antagonised effect w/ antidepressants, antipsychotics. Decreased plasma concentration w/ carbamazepine, phenobarbital, phenytoin.
Action
Ethosuximide, a succinimide derivative, suppresses paroxysmal spike-and-wave pattern common to absence seizure. It depresses nerve transmission in the motor cortex and increases seizure threshold, hence reducing the frequency of epileptiform attack.
Absorption: Readily absorbed from the GI tract. Time to peak serum concentration: 1-7 hr.
Distribution: Widely distributed throughout the body. Crosses placenta and enters breast milk. Volume of distribution: 0.7 L/kg.
Metabolism: Extensively hydroxylated in the liver to 3 inactive metabolites.
Excretion: Via urine (mainly as metabolites; 12-20% as unchanged drug). Elimination half-life: 50-60 hr.
Storage
Oral: Store between 20-25°C.
CIMS Class
Anticonvulsants
ATC Classification
N03AD01 - ethosuximide ; Belongs to the class of succinimide derivatives antiepileptics.
Disclaimer: This information is independently developed by CIMS based on ethosuximide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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