Ethyl loflazepate


Generic Medicine Info
Contraindications
Preexisting CNS depression or coma, respiratory depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; not indicated for chronic psychosis, phobic or obsessional states; may precipitate suicide or aggressive behaviour, not used alone to treat depression or anxiety associated with depression; glaucoma.
Special Precautions
Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; patients with personality disorders or organic brain changes; pregnancy, lactation; history of alcohol or drug addiction due to risk of dependence. Respiratory depression and hypotension may occur with parenteral admin.
Adverse Reactions
Drowsiness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, visual disturbances, urinary retention, GI disturbances, changes in salivation and amnesia; rarely, jaundice, blood disorders and hypersensitivity reactions; pain and thrombophlebitis; raised liver enzyme values; paradoxical excitation.
Drug Interactions
Enhanced sedation or respiratory and CV depression with drugs that have CNS depressant properties e.g. antidepressants, antihistamines, antipsychotics, general anesthetics, other hypnotics or sedatives, opioid analgesics and cisapride.
CIMS Class
ATC Classification
N05BA18 - ethyl loflazepate ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
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