Etidronate disodium


Generic Medicine Info
Contraindications
Overt osteomalacia; abnormalities of the oesophagus (e.g. stricture, achalasia) which may delay oesophagaeal emptying.
Special Precautions
Patient w/ enterocolitis. Renal impairment. Pregnancy and lactation. Patient Counselling Maintain adequate intake of Ca and vit D, good oral hygiene. Monitoring Parameters Monitor alkaline phosphatase and serum Ca levels. Perform routine dental check up.
Adverse Reactions
Paraesthesia, peripheral neuropathy, confusion, amnesia, depression, hallucination; bone/joint/muscle pain, bone fracture, GI irritation, osteonecrosis of the jaw. Rarely, burning sensation of tongue, alopecia, erythema multiforme, exacerbation of asthma, agranulocytosis or pancytopenia.
Drug Interactions
May increase prothrombin time w/ warfarin. May enhance the adverse effects of deferasirox. Decreased serum concentration w/ antacids, multivitamins/minerals. Increased hypocalcaemic effect w/ aminoglycosides. Increased adverse/toxic effect w/ NSAIDs, systemic angiogenesis inhibitors. Diminished therapeutic effect w/ PPIs.
ATC Classification
M05BA01 - etidronic acid ; Belongs to the class of bisphosphonates. Used in the treatment of bone diseases.
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