Etilefrine


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Hypotensive states
Adult: As hydrochloride: 5 or 10 mg tid. Modified-release dosage form: 25 mg once or bid.
Contraindications
Preexisting hypertension; occlusive vascular disease; pheochromocytoma; angle-closure glaucoma (eye drops); hypersensitivity; cardiac arrhythmias.
Special Precautions
CV diseases; hyperthyroidism; diabetes mellitus; Parkinson's disease; elderly; pregnancy, lactation.
Adverse Reactions
CNS effects; GI disturbances; epigastric pain; CV disorders; difficulty in micturition with urinary retention; dyspnoea; hyperglycaemia; sweating; hypersalivation; weakness, tremors; coldness of extremities; hypokalaemia; palpitations; tachycardia and arrhythmias. Gangrene.
Drug Interactions
Halogenated inhalation anaesthetics; β- or α-blocking agents; methyldopa, guanethidine; drugs with vasoconstrictor and pressor effects; antihypertensives; adrenergic neuron blockers; potassium-depleting drugs; cardiac glycosides; ephedra, yohimbe. TCAs may induce HTN and arrhythmia.
Lab Interference
Increase in bilirubin, catecholamines, glucose, uric acid.
Action
Etilefrine is a direct-acting sympathomimetic with β1-agonist and some α- and β2-agonist actions.
CIMS Class
Vasoconstrictors
ATC Classification
C01CA01 - etilefrine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.
Disclaimer: This information is independently developed by CIMS based on etilefrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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