Factor viia, recombinant

Concise Prescribing Info
Listed in Dosage.
Dosage/Direction for Use
Adult: IV Bleeding episodes in patients w/ haemophilia As activated eptacog alfa: Initial: 90 mcg/kg. May continue therapy for up to 3 wk or more in cases of serious bleeding episodes. Bleeding episodes due to surgery or invasive procedures in patients w/ factor VII deficiency As activated eptacog alfa: 15-30 mcg/kg 4-6 hrly. Bleeding episodes due to surgery or invasive procedures in Glanzmann's thrombasthenia As activated eptacog alfa: 90 mcg/kg 2 hrly, give at least 3 doses. All doses to be given via IV bolus over 2-5 min.
Hypersensitivity to hamster, bovine or mouse proteins.
Special Precautions
Patient w/ conditions associated w/ circulating tissue factor (e.g. advanced atherosclerosis, crush injury or septicaemia) due to risk of precipitating thrombosis or disseminated intravascular coagulation. Pregnancy and lactation. Monitoring Parameters Monitor prothrombin time/INR, aPTT and factor VII clotting activity prior to and after therapy.
Adverse Reactions
Nausea, vomiting, skin reactions, fever, headache and changes in BP. Rarely, anaphylaxis.
Drug Interactions
Increased risk of thromboembolism w/ activated or non-activated prothrombin complex concentrate.
CIMS Class
Disclaimer: This information is independently developed by CIMS based on factor viia, recombinant from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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