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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: IV Bleeding episodes in patients w/ haemophilia As activated eptacog alfa: Initial: 90 mcg/kg. May continue therapy for up to 3 wk or more in cases of serious bleeding episodes. Bleeding episodes due to surgery or invasive procedures in patients w/ factor VII deficiency As activated eptacog alfa: 15-30 mcg/kg 4-6 hrly. Bleeding episodes due to surgery or invasive procedures in Glanzmann's thrombasthenia As activated eptacog alfa: 90 mcg/kg 2 hrly, give at least 3 doses. All doses to be given via IV bolus over 2-5 min.
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Contraindications
Hypersensitivity to hamster, bovine or mouse proteins.
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Special Precautions
Patient w/ conditions associated w/ circulating tissue factor (e.g. advanced atherosclerosis, crush injury or septicaemia) due to risk of precipitating thrombosis or disseminated intravascular coagulation. Pregnancy and lactation. Monitoring Parameters Monitor prothrombin time/INR, aPTT and factor VII clotting activity prior to and after therapy.
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Adverse Reactions
Nausea, vomiting, skin reactions, fever, headache and changes in BP. Rarely, anaphylaxis.
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Drug Interactions
Increased risk of thromboembolism w/ activated or non-activated prothrombin complex concentrate.
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CIMS Class
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