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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: IV Replacement therapy in patients w/ haemophilia A Dosage is individualised based on coagulation test results. Recommended doses vary according to preparation used. Suggested doses: Mild-moderate haemorrhage (increase to 20-30% of normal): 10-15 u/kg as a single dose; more serious haemorrhage or minor surgery (increase to 30-50% of normal): Initial: 15-25 u/kg followed by 10-15 u/kg 8-12 hrly if required; severe haemorrhage or major surgery (increase to 80-100% of normal): Initial: 40-50 u/kg followed by 20-25 u/kg 8-12 hrly. Refer to individual product information for further dosing details. Prophylaxis in severe haemophilia A 10-50 u/kg every 2-3 days, as needed.
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Special Precautions
Risk of intravascular haemolysis in patients with blood groups A, B, or AB receiving high doses or repeated doses of factor VIII preparations. Risk of transmission of some viral infections especially hepatitis B and C. Dose requirement may vary in patients with factor VIII inhibitors; thus optimal treatment should be based on clinical response. Monitor platelet counts regularly during treatment. Pregnancy, lactation.
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Adverse Reactions
Allergic reactions e.g. chills, chest tightness, fever, headache, hyperfibrinogenaemia, jittery feeling, lethargy, nausea, vomiting, somnolence, stinging at infusion site, stomach discomfort, tingling, urticaria, vasomotor reactions with rapid infusion.
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CIMS Class
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