Factor viii


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: IV Replacement therapy in patients w/ haemophilia A Dosage is individualised based on coagulation test results. Recommended doses vary according to preparation used. Suggested doses: Mild-moderate haemorrhage (increase to 20-30% of normal): 10-15 u/kg as a single dose; more serious haemorrhage or minor surgery (increase to 30-50% of normal): Initial: 15-25 u/kg followed by 10-15 u/kg 8-12 hrly if required; severe haemorrhage or major surgery (increase to 80-100% of normal): Initial: 40-50 u/kg followed by 20-25 u/kg 8-12 hrly. Refer to individual product information for further dosing details. Prophylaxis in severe haemophilia A 10-50 u/kg every 2-3 days, as needed.
Special Precautions
Risk of intravascular haemolysis in patients with blood groups A, B, or AB receiving high doses or repeated doses of factor VIII preparations. Risk of transmission of some viral infections especially hepatitis B and C. Dose requirement may vary in patients with factor VIII inhibitors; thus optimal treatment should be based on clinical response. Monitor platelet counts regularly during treatment. Pregnancy, lactation.
Adverse Reactions
Allergic reactions e.g. chills, chest tightness, fever, headache, hyperfibrinogenaemia, jittery feeling, lethargy, nausea, vomiting, somnolence, stinging at infusion site, stomach discomfort, tingling, urticaria, vasomotor reactions with rapid infusion.
CIMS Class
Disclaimer: This information is independently developed by CIMS based on factor viii from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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