Flurazepam


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Short-term management of insomnia
Adult: 15-30 mg at night.
Child: Contraindicated.
Elderly: Max: 15 mg at night.
Administration
May be taken with or without food.
Contraindications
Patient w/ pre-existing CNS depression or coma, resp depression, acute pulmonary insufficiency, myasthenia gravis, sleep apnoea, chronic psychosis or obsessional states. Pregnancy.
Special Precautions
Patient w/ chronic pulmonary insufficiency, personality disorder, depression, resp disease, impaired gag reflex, history of alcohol or drug addiction. Renal and hepatic impairment. Childn (<15 yr), elderly or debilitated patient. Lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor resp and CV function.
Adverse Reactions
Increased risk of hazardous sleep-related activities (e.g. sleep-driving), drowsiness, light-headedness, dizziness, confusion, anterograde amnesia, headache, fatigue, reduced alertness, numbed emotions, apnoea, dyspnoea, muscle weakness, ataxia, slurred speech, double vision, vertigo, hypotension, skin rashes, GI and visual disturbances, excessive salivation, changes in libido, urinary retention.
Overdosage
Symptoms: Mental confusion, somnolence, lethargy, dysarthria, impaired vision, dystonia to ataxia, unconsciousness, central resp and/or circulatory depression, coma. Management: Symptomatic and supportive treatment. Induce vomiting or gastric lavage if taken w/in 1 hr. May admin activated charcoal to reduce absorption. Flumazenil may be used as an adjunct to proper management.
Drug Interactions
May enhance CNS depressant effect w/ antidepressants, antipsychotics, general anaesth, hypnotics or sedatives, opioid analgesics. Flurazepam clearance may be reduced by cimetidine, and may be increased by rifampicin.
Food Interaction
May increase CNS depression w/ alcohol and St John's wort. May increase serum levels w/ grapefruit juice.
Action
Flurazepam is a long-acting benzodiazepine which binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS, including the limbic system, reticular formation. It enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to Cl ions, thus resulting in hyperpolarisation and stabilisation.
Onset: Hypnotic: 15-20 min.
Duration: 7-8 hr.
Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: Approx 30-60 min.
Distribution: Crosses the placenta. Volume of distribution: 3.4 L/kg. Plasma protein binding: Approx 97%.
Metabolism: Undergoes hepatic metabolism to N-desalkylflurazepam (active) and N-hydroxyethylflurazepam.
Excretion: Via urine (mainly as conjugated metabolites). Elimination half-life: 2.3 hr (parent drug).
Storage
Oral: Store between 15-30°C.
CIMS Class
Hypnotics & Sedatives
ATC Classification
N05CD01 - flurazepam ; Belongs to the class of benzodiazepine derivatives. Used as hypnotics and sedatives.
Disclaimer: This information is independently developed by CIMS based on flurazepam from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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