Fosfomycin


Generic Medicine Info
Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity. Oral: Severe renal impairment (CrCl <10mL/min); patient undergoing haemodialysis.
Special Precautions
Patient with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatraemia, pulmonary oedema (IV). Not indicated for pyelonephritis or perinephric abscess (oral). Renal impairment or hepatic cirrhosis (IV). Premature neonates, neonates (IV); children (IV or oral [when used in acute uncomplicated cystitis]). Pregnancy and lactation. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Evaluate the effectiveness of treatment. Monitor for severe or bloody diarrhoea and perform a test to check for the presence of Clostridioides difficile. IV: Monitor serum electrolyte and fluid balance, leucocyte count; renal or liver function.
Adverse Reactions
Significant: Hepatic injury (including steatosis, hepatitis); fungal or bacterial superinfection (prolonged use). IV: Electrolyte abnormalities (e.g. hypernatraemia, hypokalaemia); haematological reactions (e.g. neutropenia, agranulocytosis). Gastrointestinal disorders: Diarrhoea, nausea, abdominal pain, dyspepsia, vomiting; dysgeusia (IV). General disorders and administration site conditions: Injection site phlebitis, asthenia (IV). Nervous system disorders: Headache, dizziness. Reproductive system and breast disorders: Vulvovaginitis (oral). Skin and subcutaneous tissue disorders: Erythematous eruption (IV).
Potentially Fatal: Hypersensitivity reactions (including anaphylaxis, anaphylactic shock); Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Drug Interactions
Decreased serum and urine levels with metoclopramide; may also result in the same effect with other drugs that increase gastrointestinal motility (e.g. bethanechol, cisapride, domperidone, laxatives).
CIMS Class
Other Antibiotics
ATC Classification
J01XX01 - fosfomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Disclaimer: This information is independently developed by CIMS based on fosfomycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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