Fosfomycin

Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.

Hypersensitivity. Oral: Severe renal impairment (CrCl <10mL/min); patient undergoing haemodialysis.

Patient with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatraemia, pulmonary oedema (IV). Not indicated for pyelonephritis or perinephric abscess (oral). Renal impairment or hepatic cirrhosis (IV). Premature neonates, neonates (IV); children (IV or oral [when used in acute uncomplicated cystitis]). Pregnancy and lactation. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Perform culture and susceptibility tests; consult local institutional recommendations before treatment initiation due to antibiotic resistance risks. Evaluate the effectiveness of treatment. Monitor for severe or bloody diarrhoea and perform a test to check for the presence of Clostridioides difficile. IV: Monitor serum electrolyte and fluid balance, leucocyte count; renal or liver function.

Significant: Hepatic injury (including steatosis, hepatitis); fungal or bacterial superinfection (prolonged use). IV: Electrolyte abnormalities (e.g. hypernatraemia, hypokalaemia); haematological reactions (e.g. neutropenia, agranulocytosis). Gastrointestinal disorders: Diarrhoea, nausea, abdominal pain, dyspepsia, vomiting; dysgeusia (IV). General disorders and administration site conditions: Injection site phlebitis, asthenia (IV). Nervous system disorders: Headache, dizziness. Reproductive system and breast disorders: Vulvovaginitis (oral). Skin and subcutaneous tissue disorders: Erythematous eruption (IV).
Potentially Fatal: Hypersensitivity reactions (including anaphylaxis, anaphylactic shock); Clostridium difficile-associated diarrhoea and pseudomembranous colitis.

Decreased serum and urine levels with metoclopramide; may also result in the same effect with other drugs that increase gastrointestinal motility (e.g. bethanechol, cisapride, domperidone, laxatives).

Other Antibiotics

J01XX01 - fosfomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.