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Administration
Should be taken on an empty stomach. Take on an empty stomach 1 hr before or 2 hr after meals.
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Contraindications
Hypersensitivity to fosfomycin.
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Special Precautions
Patient w/ cardiac insufficiency, HTN, hyperaldosteronism, hypernatraemia or pulmonary oedema. Renal impairment (IV). Pregnancy and lactation. Patient Counselling Certain adverse effects may occur which may impair ability to drive or operate machinery. Monitoring Parameters Monitor serum electrolyte levels and water balance; signs and symptoms of UTI.
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Adverse Reactions
GI disturbances (e.g. nausea, diarrhoea), transient increase in aminotransferase levels, headache, visual disturbances, skin rashes, eosinophilia, angioedema, aplastic anaemia, exacerbation of asthma, cholestatic jaundice, hepatic necrosis, toxic megacolon.
Potentially Fatal: Anaphylactic shock, antibiotic-associated colitis and pseudomembranous colitis. |
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Drug Interactions
Additive or synergistic effect w/ β-lactam antibiotics (e.g. penicillin, ampicillin, cefazolin, carbapenems) and anti-staphylococcal agents (e.g. linezolid, quinupristin/dalfopristin, moxifloxacin). Reduced serum levels w/ drugs which increase GI motility (e.g. metoclopramide).
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CIMS Class
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ATC Classification
J01XX01 - fosfomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
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