Framycetin


Full Generic Medicine Info
Dosage/Direction for Use

Otic/Aural
Otitis externa
Adult: As 0.5% solution: Instill 2-3 drops into the external auditory meatus tid. Max treatment duration: 2 weeks.
Child: Same as adult dose.

Ophthalmic
Bacterial conjunctivitis
Adult: As 0.5% solution or ointment: For rapid relief in acute conditions: Instill 1-2 drops to affected eye(s) 1-2 hourly for the 1st 2-3 days. Reduce to 1-2 drops 3-4 times daily when there is improvement.
Child: Same as adult dose.

Ophthalmic
Blepharitis
Adult: As 0.5% solution or ointment: For rapid relief in acute conditions: Instill 1-2 drops to affected eye(s) 1-2 hourly for the 1st 2-3 days. Reduce to 1-2 drops 3-4 times daily when there is improvement.
Child: Same as adult dose.

Ophthalmic
Stye
Adult: As 0.5% solution or ointment: For rapid relief in acute conditions: Instill 1-2 drops to affected eye(s) 1-2 hourly for the 1st 2-3 days. Reduce to 1-2 drops 3-4 times daily when there is improvement.
Child: Same as adult dose.

Ophthalmic
Corneal abrasion
Adult: As 0.5% solution or ointment: For rapid relief in acute conditions: Instill 1-2 drops to affected eye(s) 1-2 hourly for the 1st 2-3 days. Reduce to 1-2 drops 3-4 times daily when there is improvement.
Child: Same as adult dose.

Topical/Cutaneous
Wounds, burns, ulcers and skin infections
Adult: As dressing containing framycetin 1%: Apply a single layer directly to the wound. Change the dressing at least daily if wound is exudative. For leg ulcers, cut the dressing accurately to size of ulcer to avoid contact with surrounding healthy skin and to reduce the risk of sensitisation.
Contraindications
Hypersensitivity to framycetin or other aminoglycoside antibacterials (neomycin, kanamycin). Perforated tympanic membrane (otic).
Special Precautions
Children. Pregnancy and lactation. Patient Counselling Ophthalmic: This drug may cause blurred vision, if affected, do not drive or operate machinery. If you are wearing contact lenses, remove prior to application and reinsert after 15 minutes. Monitoring Parameters Monitor improvement of infection/symptoms.
Adverse Reactions
Significant: Bacterial or fungal superinfection (prolonged use). Ear and labyrinth disorders: Inner ear damage. Eye disorders: Eye irritation, superficial punctate keratitis, delayed corneal epithelial wound healing, retinal toxicity (if there is leakage through corneoscleral wound). Immune system disorders: Hypersensitivity reactions.
Action
Framycetin is an aminoglycoside bactericidal antibiotic. Its exact mechanism of action has not been fully elucidated; however, it appears to inhibit protein synthesis in susceptible bacteria by binding to ribosomal subunits. Framycetin is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria.
Storage
Ophthalmic: Store between 15-25°C. Otic/Aural: Store between 15-25°C. Topical/Cutaneous: Store between 15-25°C.
CIMS Class
Ear Anti-Infectives & Antiseptics / Eye Anti-Infectives & Antiseptics / Topical Antibiotics
ATC Classification
S01AA07 - framycetin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
D09AA01 - framycetin ; Belongs to the class of ointment dressings with antiinfectives.
R01AX08 - framycetin ; Belongs to the class of other nasal preparations for topical use.
Disclaimer: This information is independently developed by CIMS based on framycetin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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