Ganciclovir


Generic Medicine Info
Administration
Should be taken with food.
Contraindications
Hypersensitivity to ganciclovir or valganciclovir and other antivirals (e.g. aciclovir, valaciclovir).
Special Precautions
Patient w/ pre-existing cytopenias or a history of cytopenic reactions to other drugs, chemicals or radiation therapy. Renal impairment. Pregnancy and lactation. Patient Counselling This drug may cause convulsion, sedation, ataxia and/or confusion, if affected, do not drive or operate machinery. Monitoring Parameters Monitor haematological function (CBC w/ differential and platelet count), serum creatinine.
Adverse Reactions
Haematologic effects (e.g. neutropenia, thrombocytopenia, anaemia, eosinophilia); headache, seizure, coma, confusion, thought disorders, dysphoria, agitation, hallucinations, abnormal dreams/nightmares, nervousness/anxiety, delirium, dizziness, dysaesthesia, asthenia, intention tremor, abnormal reflexes, ataxia, paraesthesia, psychosis, somnolence, obtundation; elevated serum aminotransferase and alkaline phosphatase levels; nausea, vomiting, diarrhoea, anorexia, GI haemorrhage, abdominal pain; increased serum creatinine and BUN levels, haematuria; inflammation, phlebitis and/or pain at inj site; burning or brief tingling sensations, superficial punctate keratitis, visual disturbance (ophth); fever, rash, oedema, myalgia, chills, malaise, cardiac arrhythmia, MI, cardiac arrest, HTN, hypotension, hypoglycaemia, dyspnoea, alopecia, urticaria, pruritus, hyponatraemia, deafness, syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Drug Interactions
Increased risk of haematologic toxicity w/ zidovudine. May increase serum levels of didanosine. Increased serum concentration w/ probenecid and other drugs that inhibit renal tubular secretion and resorption. Use of IV ganciclovir w/ oral mycophenolate mofetil may result in increased plasma concentrations of both drugs due to competition for renal tubular secretion. Concomitant use w/ immunosuppressive agents (e.g. azathioprine, ciclosporin, corticosteroids) may result in excessive suppression of bone marrow or the immune system. Generalised seizure may occur when taken w/ imipenem and cilastatin. Concurrent use w/ drugs that inhibit replication of rapidly dividing cells (e.g. dapsone, pentamidine, pyrimethamine, flucytosine, cytotoxic antineoplastic agents, amphotericin B, co-trimoxazole, other nucleoside analogues) may result in additive toxicity.
CIMS Class
Antivirals
ATC Classification
J05AB06 - ganciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
S01AD09 - ganciclovir ; Belongs to the class of antiinfectives, antivirals. Used in the treatment of eye infections.
Disclaimer: This information is independently developed by CIMS based on ganciclovir from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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