Gatifloxacin

Bacterial conjunctivitis.

Adult: Ophth As 0.3% soln: Instill 1 drop 2 hrly into affected eye(s) while awake (up to 8 times/day) for the 1st 2 days then reduce to 1 drop 4 times/day while awake for the next 5 days.

Known hypersensitivity to gatifloxacin, other quinolones.

Medication should not to be introduced into the anterior chamber of the eye. Pregnancy and lactation. Patient Counselling Contact lenses should not be worn during treatment. Avoid contamination of the applicator tip w/ material from the eye, fingers or other sources. Monitoring Parameters Monitor signs of infection. Slit-lamp biomicroscopy and fluorescein staining may be necessary for careful monitoring.

Conjunctival irritation, increased lacrimation, keratitis, papillary conjunctivitis, chemosis, conjunctival haemorrhage, ocular dryness and redness, ocular discharge/irritation/pain, eyelid oedema, headache, reduced visual acuity, and taste disturbance.
Potentially Fatal: Hypersensitivity reactions including anaphylaxis; fungal or bacterial superinfection.

Additive effect w/ drugs that prolong QT interval e.g. antiarrhythmic agents (amiodarone, quinidine, sotalol), arsenic trioxide, cisapride, chlorpromazine, droperidol, mefloquine, dolasetron, mesoridazine, moxifloxacin, pimozide, tacrolimus, pentamidine, thioridazine, ziprasidone. Increased risk of blood glucose disturbances w/ drugs that alter blood glucose concentrations (e.g. antidiabetics). Systemic admin may elevate plasma concentrations of theophylline, interfere caffeine metabolism, enhance effects of oral anticoagulant (warfarin and its derivatives), and transient elevations in serum creatinine w/ ciclosporin.

Eye Anti-Infectives & Antiseptics / Quinolones

J01MA16 - gatifloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
S01AE06 - gatifloxacin ; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.