Glimepiride


Generic Medicine Info
Administration
Should be taken with food. Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.
Contraindications
Hypersensitivity to glimepiride, other sulfonylureas or sulfonamides. Type 1 diabetes or insulin-dependent diabetes, and diabetic ketoacidosis (with or without coma). Severe renal or hepatic impairment.
Special Precautions
Patient with G6PD deficiency, stress-related states (e.g. fever, trauma, infection, surgery). Mild to moderate renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling This drug may cause hypoglycaemia and visual disturbances, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood and urine glucose, glycosylated Hb level, renal function, signs and symptoms of hypoglycaemia. Regular hepatic and haematological monitoring (leukocytes and thrombocytes).
Adverse Reactions
Significant: Hypoglycaemia, haemolytic anaemia (in G6PD deficiency), hypersensitivity reaction (e.g. anaphylaxis, angioedema, Stevens-Johnson syndrome), weight gain. Blood and lymphatic system disorders: Leukopenia, agranulocytosis, aplastic anaemia, pancytopenia, thrombocytopenia. Endocrine disorders: Inappropriate antidiuretic hormone secretion (SIADH). Eye disorders: Visual disturbances. Gastrointestinal disorders: Abdominal pain, diarrhoea, nausea, vomiting, dysgeusia. General disorders and administration site conditions: Asthenia. Hepatobiliary disorders: Cholestasis, jaundice, hepatitis, liver failure, hepatic porphyria. Metabolism and nutrition disorders: Disulfiram-like reactions, hyponatraemia. Nervous system disorders: Headache, dizziness. Skin and subcutaneous tissue disorders: Photosensitivity, alopecia.
Drug Interactions
Increased hypoglycaemic effect with NSAIDs (e.g. phenylbutazone), insulin, oral antidiabetics (e.g. metformin), salicylates, fluoxetine, anabolic steroids and androgens, antibiotics (e.g. chloramphenicol, sulphonamides, tetracyclines, quinolones, clarithromycin), coumarin anticoagulants, disopyramide, fibrates, ACE inhibitors, MAOIs, allopurinol, probenecid, sulfinpyrazone, cyclophosphamide, fluconazole and pentoxifylline. Decreased hypoglycaemic effect with oestrogens, oral contraceptives, thiazide diuretics, glucocorticoids, phenothiazine derivatives (e.g. chlorpromazine), sympathomimetics (e.g. epinephrine, albuterol, terbutaline), nicotinic acid (high doses) and nicotinic acid derivatives, laxative (long term use), phenytoin, diazoxide, glucagon, barbiturates, rifampicin and isoniazid. Signs of hypoglycaemia may be reduced or absent in patients taking sympatholytic drugs (e.g. β-blockers, clonidine, guanethidine, reserpine). May cause severe hypoglycaemia with miconazole.
CIMS Class
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
Disclaimer: This information is independently developed by CIMS based on glimepiride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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