Glucose


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Hypoglycaemia
Adult: 75 g as a single dose.
Child: 15-20 g as a single dose, repeat after 15 min if necessary.

Oral
Oral glucose tolerance test
Adult: 75 g as a single dose.

Intravenous
Fluid depletion
Adult: As 5% soln given via peripheral vein. Dosage is based on individual patient requirements.

Intravenous
Carbohydrate depletion
Adult: As >5% soln given via peripheral vein. Dosage is based on individual patient requirements.

Intravenous
Hypoglycaemia
Adult: 10-25 g (40-100 mL of 25% soln or 20-50 mL of 50% soln) as a single dose via central vein, repeat if necessary in severe cases.
Child: 0.5-1 g/kg/dose. Max: 25 g/dose.
Contraindications
Hypersensitivity to glucose, corn or corn products. Patient w/ severe dehydration, glucose-galactose malabsorption syndrome, ischaemic stroke. Admin of hypertonic soln in patients (esp if dehydrated) w/ intracranial or intraspinal haemorrhage, diabetic coma, delirium tremens.
Special Precautions
Patient w/ DM, chronic uraemia, thiamine deficiency, severe traumatic brain injury, water and electrolyte imbalance, haemodilution, sepsis, and severe malnutrition. Avoid abrupt withdrawal. Renal failure. Childn (esp low birth wt infants). Pregnancy and lactation. Monitoring Parameters Monitor serum and urine glucose, serum electrolytes, intake and output (I & O), caloric intake.
Adverse Reactions
Significant: Electrolyte imbalance (e.g. hypokalaemia), dehydration, extravasation, severe hypersensitivity reactions (e.g. anaphylaxis). Nervous: Confusion, loss of consciousness. CV: Localised phlebitis, venous irritation and thrombosis, thrombophlebitis. Resp: Pulmonary vascular precipitates and oedema. Hepatic:Hepatic failure, cirrhosis, cholestasis, steatosis, increased bilirubin and hepatic enzyme, cholecystitis, cholelithiasis. Genitourinary: Diuresis. Endocrine: Glycosuria, hyperosmolar syndrome, hypervolaemia. Dermatologic: Rash. Others: Catheter infection and sepsis, chills, fever, infusion site reactions (e.g. erythema and pain).
Potentially Fatal: Severe hyperglycaemia and hyponatraemia.
Overdosage
Symptoms: Hyperglycaemia, water intoxication or oedema, and glycosuria. Management: Symptomatic and supportive treatment.
Action
Glucose, the natural sugar occurring in blood, is the primary source of energy in cellular metabolism. It is readily converted to fat which provides a rich store of energy in concentrated form, and it also promotes glycogen deposition in the liver.
Onset: 10 min (oral).
Absorption: Rapidly absorbed from the GI tract. Bioavailability: 100% (IV). Time to peak plasma concentration: Approx 40 min (oral).
Metabolism: Metabolised in the liver by pyruvic or lactic acid to CO2 and water w/ energy release.
Storage
Intravenous: Store below 25°C. Protect from extreme heat. Do not freeze. Oral: Store below 25°C. Protect from extreme heat. Do not freeze.
CIMS Class
Intravenous & other sterile solutions / Other Agents Affecting Metabolism
ATC Classification
V06DC01 - glucose ; Belongs to the class of carbohydrates used as general nutrients.
V04CA02 - glucose ; Belongs to the class of diagnostic agents used to test for diabetes.
B05CX01 - glucose ; Belongs to the class of other solutions used as irrigating solutions.
Disclaimer: This information is independently developed by CIMS based on glucose from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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