Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: SC Palliation of prostatic carcinoma 3.6 mg every 28 days or 10.8 mg every 12 wk. Pituitary desensitisation before ovulation induction w/ gonadotrophins Depot 3.6 mg.
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Contraindications
Hypersensitivity; pregnancy, lactation.
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Special Precautions
Urinary tract obstruction or spinal cord compression (when used for prostate cancer); decreased bone density in women. Contraceptive measures should be taken to protect against pregnancy. Monitor men at risk from tumour flare during the 1st mth of therapy. Safety and efficacy on the usage of the 10.8 mg implant in women is not established.
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Adverse Reactions
Vaginal bleeding and dryness, arthralgia, paraesthesias, increase in menstrual bleeding, hot flushes, sexual dysfunction. Headache, emotional lability, depression, insomnia, diaphoresis, dizziness, breast swelling/tenderness, Inj site reactions. Anaphylaxis.
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ROUTE(S) : SC: D
In patients w/ advanced breast cancer
ROUTE(S) : SC: X
In patients w/ endometriosis & endometrial thinning
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ATC Classification
L02AE03 - goserelin ; Belongs to the class of gonadotropin releasing hormone analogues. Used in endocrine therapy.
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