Guanethidine


Generic Medicine Info
Contraindications
Phaeochromocytoma, heart failure unrelated to hypertension. Concomitant use or within 2 weeks of MAOIs. Severe renal impairment (CrCl 10-40 mL/min).
Special Precautions
Patient with coronary or cerebral artery disease, asthma, history of gastrointestinal ulceration, Parkinson's disease with associated autonomic neuropathy. Moderate renal impairment (CrCl 41-65 mL/min). Pregnancy (not recommended during the 1st trimester or within 2 weeks before labour), and lactation. Withdraw treatment few days prior to surgery. Patient Counselling This drug may cause dizziness, drowsiness, or blurred vision, if affected, do not drive or operate machinery. Monitoring Parameters Monitor blood pressure and renal function.
Adverse Reactions
Significant: CNS effect (e.g. dizziness, blurred vision, drowsiness), latent heart failure (prolonged use), fever. Cardiac disorders: Bradycardia, sick-sinus syndrome. Gastrointestinal disorders: Nausea, diarrhoea, vomiting, dry mouth, gaseous distension. General disorders and administration site conditions: Lethargy, oedema, tiredness. Investigations: Increased BUN levels (in patients with latent or manifest renal failure). Nervous system disorders: Headache, paraesthesia. Renal and urinary disorders: Uraemia (in patients with latent or manifest renal failure). Reproductive system and breast disorders: Ejaculation disturbances, erectile dysfunction (including priapism). Respiratory, thoracic and mediastinal disorders: Rarely, asthma. Vascular disorders: Postural hypotension, exacerbation of intermittent claudication.
Drug Interactions
May lead to sinus bradycardia when given concurrently with antiarrhythmic agents and digitalis. Antihypertensive effect may be increased by reserpine, methyldopa, vasodilators (e.g. minoxidil), calcium channel blockers, β-blockers, ACE inhibitors. Antihypertensive effect may be decreased by TCAs, phenothiazine derivatives, chlorpromazine, oral contraceptives. May increase hypersensitivity to adrenaline, amphetamines, or other sympathomimetic agents.
CIMS Class
Other Antihypertensives
ATC Classification
C02CC02 - guanethidine ; Belongs to the class of guanidine derivatives, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
S01EX01 - guanethidine ; Belongs to the class of other antiglaucoma preparations.
Disclaimer: This information is independently developed by CIMS based on guanethidine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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