Generic Medicine Info
Significant respiratory depression, acute or severe bronchial asthma (in unmonitored setting), known or suspected gastrointestinal obstruction (e.g. paralytic ileus). Children <18 years.
Special Precautions
Patient with heart failure, electrolyte abnormalities, bradyarrhythmias, hypovolaemia, CV disease (e.g. MI), impaired consciousness or coma, delirium tremens, thyroid dysfunction, adrenocortical insufficiency (e.g. Addison's disease), prostatic hypertrophy, urethral stricture, head injury, intracranial lesions, increased intracranial pressure, history of seizure disorder, mental health conditions (e.g. anxiety), toxic psychosis, acute abdominal conditions, biliary tract dysfunction, acute pancreatitis, morbid obesity, COPD or cor pulmonale, risk factors for sleep-disordered breathing. Avoid abrupt withdrawal. Moderate to severe renal or severe hepatic impairment. Pregnancy (prolonged use may result in neonatal opioid withdrawal syndrome) and lactation. Patient Counselling This drug may impair mental and physical abilities, if affected, do not drive or operate machinery. Monitoring Parameters Monitor pain relief, respiratory and mental status, BP; signs of misuse, abuse, and addiction; signs or symptoms of hypogonadism or hypoadrenalism.
Adverse Reactions
Significant: QT prolongation, constipation, severe hypotension (including orthostatic hypotension, syncope), sedation. Cardiac disorders: Hypertension. Gastrointestinal disorders: Nausea, vomiting, dyspepsia, gastroenteritis, upper abdominal pain, diarrhoea, abdominal pain, decreased appetite, xerostomia, abdominal distress, GERD. General disorders and administration site conditions: Fever, fatigue. Investigations: Increased gamma-glutamyl transferase, increased cholesterol. Metabolism and nutrition disorders: Dehydration, hypokalaemia, increased appetite Musculoskeletal and connective tissue disorders: Back pain, muscle spasm, tremor, arthralgia, bone fracture, injury to the joint, joint sprain, limb pain, musculoskeletal pain, myalgia, neck pain, osteoarthritis, chills. Nervous system disorders: Dizziness, headache, chills, migraine, paresthesia. Psychiatric disorders: Euphoria, dysphoria, anxiety, insomnia, depression. Renal and urinary disorders: UTI. Respiratory, thoracic and mediastinal disorders: Bronchitis, nasal congestion, nasopharyngitis, oropharyngeal pain, sinusitis, upper respiratory tract infection, cough, dyspnoea. Skin and subcutaneous tissue disorders: Rash, pruritus, hyperhidrosis, night sweats. Vascular disorders: Hot flush.
Potentially Fatal: Respiratory depression.
Drug Interactions
Concurrent use with anticholinergic agents may increase risk of urinary retention which may lead to paralytic ileus. Strong laxatives (e.g. lactulose) may decrease absorption and plasma concentration of hydrocodone. Decreased efficacy with CYP3A4 inducers. Risk of serotonin syndrome with serotonergic drugs (e.g. TCAs, SSRIs, MAOIs). Reduced analgesic effect with mixed agonist/antagonist (e.g. nalbuphine) or partial agonist (e.g. buprenorphine) analgesics, may precipitate withdrawal symptoms. May enhance the neuromuscular blocking effect of skeletal muscle relaxants. May reduce the efficacy of diuretics.
CIMS Class
ATC Classification
R05DA03 - hydrocodone ; Belongs to the class of opium alkaloids and derivatives. Used as cough suppressant.
Disclaimer: This information is independently developed by CIMS based on hydrocodone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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