Generic Medicine Info
Obstructive uropathy (e.g. bladder neck obstruction due to prostatic hypertrophy), myasthenia gravis, glaucoma; obstructive gastrointestinal tract disease (e.g. achalasia, pyloroduodenal stenosis), paralytic ileus, severe ulcerative colitis, toxic megacolon complicating ulcerative colitis, intestinal atony (in elderly or debilitated patients); unstable CV status; myocardial ischaemia.
Special Precautions
Patients with coronary artery disease, tachyarrhythmias, heart failure, hypertension; hiatal hernia with reflux oesophagitis, hyperthyroidism, autonomic neuropathy. Febrile patients or those subjected to increased environmental temperature (e.g. hot weather, exercise). Renal impairment. Children (including those with spastic paralysis or brain damage) and elderly. Pregnancy and lactation. Patient Counselling This drug may cause drowsiness, dizziness, or blurred vision, if affected, do not drive or operate machinery. Monitoring Parameters Assess for signs of tachycardia prior to treatment initiation. Observe for excessive dryness of the mouth, throat, nose, or eyes.
Adverse Reactions
Significant: Diarrhoea (particularly in patients with ileostomy or colostomy), heat prostration (e.g. fever, heat stroke due to decreased sweating); psychosis (particularly in patients with increased sensitivity to anticholinergic effects); dental caries, periodontal disease, oral candidiasis, discomfort due to decreased salivation (prolonged use). Cardiac disorders: Tachycardia, palpitations. Eye disorders: Blurred vision, mydriasis, cycloplegia, increased intraocular pressure. Gastrointestinal disorders: Abdominal pain, nausea, vomiting, constipation, ageusia, bloating, dysgeusia, dysphagia, heartburn, xerostomia. General disorders and administration site conditions: Fatigue, weakness, fever. Immune system disorders: Hypersensitivity reaction. Nervous system disorders: Short-term memory loss; excitement (particularly in elderly); dizziness, drowsiness, headache, nervousness, speech disturbance, ataxia. Psychiatric disorders: Hallucination, insomnia, confusion, disorientation, euphoria, anxiety, agitation and mannerisms. Renal and urinary disorders: Urinary retention and hesitancy. Reproductive system and breast disorders: Decreased lactation, impotence. Skin and subcutaneous tissue disorders: Hypohidrosis, urticaria. Vascular disorders: Flushing.
Drug Interactions
May increase adverse effects resulting from cholinergic blockade with other antimuscarinics, haloperidol, MAOIs, phenothiazines, TCAs, certain antihistamines; amantadine. May decrease absorption with antacids.
CIMS Class
Antacids, Antireflux Agents & Antiulcerants / Antidotes, Detoxifying Agents & Drugs Used in Substance Dependence / Antispasmodics / Muscle Relaxants
ATC Classification
A03BA03 - hyoscyamine ; Belongs to the class of belladonna alkaloids, tertiary amines. Used in the treatment of functional gastrointestinal disorders.
Disclaimer: This information is independently developed by CIMS based on hyoscyamine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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