Idebenone


Generic Medicine Info
Special Precautions
Ensure that chromaturia does not mask colour changes due to other reasons (e.g. renal or blood disorders). Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor patient regularly according to local clinical guidelines.
Adverse Reactions
Significant: Chromaturia (reddish-brown urine discolouration). General disorders and administration site conditions: Malaise. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, dyspepsia. Musculoskeletal and connective tissue disorders: Back pain, pain in the extremity. Nervous system disorders: Headache, dizziness. Respiratory, thoracic and mediastinal disorders: Nasopharyngitis, cough. Skin and subcutaneous tissue disorders: Rash, pruritus.
Drug Interactions
Repeated administration may increase the serum concentrations of CYP3A4 substrates (e.g. midazolam, terfenadine, cisapride, ciclosporin, fentanyl, pimozide, quinidine, tacrolimus, ergotamine). May inhibit P-glycoprotein which may increase the exposure of dabigatran etexilate, digoxin, or aliskiren.
ATC Classification
N06BX13 - idebenone ; Belongs to the class of other psychostimulants and nootropics.
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