Iloprost


Generic Medicine Info
Contraindications
Pulmonary oedema, pulmonary hypertension due to venous occlusive disease, congenital or acquired valvular defects with clinically relevant myocardial function disorders not related to pulmonary hypertension, systolic blood pressure below 85 mmHg, acute or chronic CHF (NYHA II-IV), severe coronary heart disease or unstable angina, MI within the last 6 months, decompensated cardiac failure (unless under close medical supervision), severe arrhythmias, cerebrovascular events (e.g. TIA, stroke) within the last 3 months, active peptic ulcers, trauma, intracranial haemorrhage. IV: Pregnancy and lactation.
Special Precautions
Patient with active COPD, severe asthma, acute pulmonary infections. Avoid abrupt withdrawal. Renal and hepatic impairment. Inhalation: Pregnancy and lactation. Patient Counselling This medicine may cause dizziness, if affected, do not drive or operate machinery. Avoid contact to mucous membranes. Monitoring Parameters Monitor heart rate, blood pressure, respiratory rate and for improvements of pulmonary function.
Adverse Reactions
Significant: Syncope. Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal discomfort, abdominal pain. General disorders and administration site conditions: Pain, pyrexia, chills, infusion site reactions (e.g. pain, erythema, phlebitis). Metabolism and nutrition disorders: Decreased appetite. Musculoskeletal and connective tissue disorders: Jaw pain, myalgia, arthralgia, trismus. Nervous system disorders: Dizziness, headache, palpitations, restlessness, drowsiness. Psychiatric disorders: Confusional state. Respiratory, thoracic and mediastinal disorders: Cough, throat irritation. Skin and subcutaneous tissue disorders: Rash, hyperhidrosis. Vascular disorders: Flushing, vasodilation.
Potentially Fatal: Cerebrovascular stroke, myocardial infarction, pulmonary embolism, cardiac failure, convulsion, hypotension, tachycardia, asthma, angina pectoris, dyspnoea, pulmonary oedema, cerebral and intracranial haemorrhage.
Drug Interactions
Additive hypotensive effect with other vasodilators and antihypertensive agents. Increased risk of bleeding with anticoagulants and platelet aggregation inhibitors.
ATC Classification
B01AC11 - iloprost ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis.
Disclaimer: This information is independently developed by CIMS based on iloprost from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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