Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Onchocerciasis 150 mcg/kg as single dose; repeat treatment every 3-12 mth until symptoms resolved. Strongyloidiasis 200 mcg/kg for 1-2 days. Topical Rosacea As 1% cream: Apply onto affected area(s) once daily for up to 4 mth, repeat treatment course if needed. Head pediculosis As 0.5% lotion: Apply sufficient amount into dry hair and scalp as single dose, then leave on for 10 min before rinsing.
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Administration
Should be taken on an empty stomach. Take on an empty stomach.
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Special Precautions
Patient w/ onchocerciasis and loiasis. Immunocompromised patients. Childn. Pregnancy and lactation. Patient Counselling Avoid contact w/ eyes and lips. Monitoring Parameters Assess for loiasis prior to therapy. Monitor for presence of larvae in stool, 3-4 wk post-therapy; skin and eye microfilarial counts; ophthalmological conditions.
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Adverse Reactions
Significant: Mazzotti reaction (e.g. oedema, pruritus, urticaria rash, lymphadenitis, arthralgia, synovitis, fever, sore throat, cough, headache, tachycardia, orthostatic hypotension, oedema).
Nervous: Dizziness, asthenia, fatigue, somnolence, vertigo, tremor.
GI: Diarrhoea, abdominal pain, nausea, anorexia, constipation, vomiting.
Hepatic: Increased serum ALT, AST.
Haematologic: Eosinophilia, decreased WBC, increased Hb.
Ophthalmologic: Conjunctivitis, ocular hyperemia, irritation (topical); limbitis, punctate opacity, abnormal sensation, eyelid oedema, anterior uveitis, conjunctival haemorrhage (oral).
Dermatologic: Burning sensation, irritation, itch, dry skin, contact dermatitis, erythema (topical).
Potentially Fatal: Rarely, encephalopathy. |
Drug Interactions
Increased serum concentration w/ P-glycoprotein inhibitors. Decreased serum concentration w/ P-glycoprotein inducers. Enhanced anticoagulant effect of vit K antagonists (e.g. warfarin). Diminished therapeutic effect of lactobacillus and estriol.
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CIMS Class
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ATC Classification
D11AX22 - ivermectin ; Belongs to the class of other dermatologicals.
P02CF01 - ivermectin ; Belongs to the class of avermectine agents. Used as antinematodal. |