Ivermectin


Generic Medicine Info
Administration
Should be taken on an empty stomach. Take on an empty stomach.
Contraindications
Hypersensitivity.
Special Precautions
Patient with loiasis (heavy infection of Loa loa); hyperreactive onchodermatitis (sowda). Immunocompromised (including HIV-infected) patients. No activity against adult Onchocerca volvulus parasites. Severe hepatic impairment (topical cream). Children. Pregnancy and lactation. Patient Counselling Topical: Avoid contact with eyes and lips. Monitoring Parameters Evaluate pregnancy status before use in patients who may become pregnant. Assess for loiasis before and after therapy (especially in patients with significant exposure to Loa loa endemic areas of West and Central Africa). Obtain skin and eye microfilarial counts; periodic ophthalmologic exams. Perform follow-up stool examination (for intestinal strongyloidiasis).
Adverse Reactions
Significant: Mazzotti reaction (e.g. lymphadenitis, oedema, arthralgia, synovitis, tachycardia, fever, pruritus, urticaria) and ophthalmic reaction particularly in patients undergoing treatment for onchocerciasis; transient aggravation of rosacea (topical cream). Blood and lymphatic system disorders: Transient eosinophilia, leucopenia, anaemia. Eye disorders: Conjunctival haemorrhage (if treated for onchocerciasis); conjunctivitis, ocular hyperaemia, eye irritation (topical lotion). Ear and labyrinth disorders: Vertigo. Gastrointestinal disorders: Abdominal pain, constipation, diarrhoea, nausea, vomiting. General disorders and administration site conditions: Asthenia, fatigue. Investigations: Increased AST, ALT, and bilirubin. Metabolism and nutrition disorders: Anorexia. Nervous system disorders: Dizziness, tremor, seizures. Psychiatric disorders: Somnolence. Respiratory, thoracic and mediastinal disorders: Worsening of bronchial asthma. Skin and subcutaneous tissue disorders: Rash, Stevens-Johnson syndrome, toxic epidermal necrolysis (oral); dandruff (topical lotion); skin burning sensation, irritation, pruritus, dry skin (topical cream/lotion). Vascular disorders: Orthostatic hypotension.
Potentially Fatal: Rarely, encephalopathy (especially if the patient with onchocerciasis is co-infected with Loa loa).
Drug Interactions
Rarely, increased INR with warfarin.
CIMS Class
Anthelmintics / Other Dermatologicals
ATC Classification
D11AX22 - ivermectin ; Belongs to the class of other dermatologicals.
P02CF01 - ivermectin ; Belongs to the class of avermectine agents. Used as antinematodal.
Disclaimer: This information is independently developed by CIMS based on ivermectin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in