Ivermectin

Listed in Dosage.

Adult: PO Onchocerciasis 150 mcg/kg as single dose; repeat treatment every 3-12 mth until symptoms resolved. Strongyloidiasis 200 mcg/kg for 1-2 days. Topical Rosacea As 1% cream: Apply onto affected area(s) once daily for up to 4 mth, repeat treatment course if needed. Head pediculosis As 0.5% lotion: Apply sufficient amount into dry hair and scalp as single dose, then leave on for 10 min before rinsing.

Should be taken on an empty stomach. Take on an empty stomach.

Patient w/ onchocerciasis and loiasis. Immunocompromised patients. Childn. Pregnancy and lactation. Patient Counselling Avoid contact w/ eyes and lips. Monitoring Parameters Assess for loiasis prior to therapy. Monitor for presence of larvae in stool, 3-4 wk post-therapy; skin and eye microfilarial counts; ophthalmological conditions.

Significant: Mazzotti reaction (e.g. oedema, pruritus, urticaria rash, lymphadenitis, arthralgia, synovitis, fever, sore throat, cough, headache, tachycardia, orthostatic hypotension, oedema). Nervous: Dizziness, asthenia, fatigue, somnolence, vertigo, tremor. GI: Diarrhoea, abdominal pain, nausea, anorexia, constipation, vomiting. Hepatic: Increased serum ALT, AST. Haematologic: Eosinophilia, decreased WBC, increased Hb. Ophthalmologic: Conjunctivitis, ocular hyperemia, irritation (topical); limbitis, punctate opacity, abnormal sensation, eyelid oedema, anterior uveitis, conjunctival haemorrhage (oral). Dermatologic: Burning sensation, irritation, itch, dry skin, contact dermatitis, erythema (topical).
Potentially Fatal: Rarely, encephalopathy.

Increased serum concentration w/ P-glycoprotein inhibitors. Decreased serum concentration w/ P-glycoprotein inducers. Enhanced anticoagulant effect of vit K antagonists (e.g. warfarin). Diminished therapeutic effect of lactobacillus and estriol.

Other Dermatologicals / Anthelmintics

D11AX22 - ivermectin ; Belongs to the class of other dermatologicals.
P02CF01 - ivermectin ; Belongs to the class of avermectine agents. Used as antinematodal.