Lactulose


Generic Medicine Info
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort. Dilute w/ water, milk, or fruit juice to improve taste.
Contraindications
Galactosaemia, gastrointestinal obstruction or subocclusive syndromes, acute inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease); existing or at risk of gastrointestinal perforation, painful abdominal syndromes of an unknown cause; patient requiring a low galactose diet.
Special Precautions
Patient with lactose intolerance, diabetes mellitus, gastro-cardiac syndrome (Roemheld syndrome); undergoing electrocautery procedures during proctoscopy or colonoscopy. Not recommended for use in patients with rare hereditary problems of galactose or fructose intolerance, the total lactase deficiency or glucose-galactose malabsorption. Reconsider dose and/or other additional measures if insufficient therapeutic effect is observed. Debilitated patients. Infants, children, and elderly. Pregnancy and lactation. Patient Counselling Drink sufficient amounts of fluids (1.5-2 L or 6-8 glasses daily). Monitoring Parameters Evaluate painful abdominal symptoms of an unknown cause prior to treatment initiation. Monitor blood pressure, serum electrolytes, serum ammonia, fluid status, and bowel movement frequency/consistency.
Adverse Reactions
Significant: Electrolyte imbalance, diarrhoea (long-term treatment or excessive doses). Gastrointestinal disorders: Nausea, vomiting, flatulence, abdominal pain. Metabolism and nutrition disorders: Dehydration.
Drug Interactions
May diminish the therapeutic effect with glutamine. May increase the risk of K loss caused by thiazides, corticosteroids, and amphotericin B. May increase the effects of cardiac glycosides. Non-absorbable antacids, neomycin, or other anti-infectives may cause a decrease in the desired effect of treatment with lactulose.
CIMS Class
Laxatives, Purgatives
ATC Classification
A06AD11 - lactulose ; Belongs to the class of osmotically acting laxatives.
Disclaimer: This information is independently developed by CIMS based on lactulose from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 CIMS. All rights reserved. Powered by CIMSAsia.com
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