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Contraindications
Hypovolaemia, complete heart block, Adam-Stokes syndrome, Wolff-Parkinson-White syndrome. Must not be applied to inflamed or injured skin.
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Special Precautions
Patient w/ pseudocholinesterase deficiency, cardiac conduction disturbances, resp depression. Hepatic and renal impairment. Elderly or debilitated patients. Pregnancy and lactation. Patient Counselling May cause temporary loss of sensation and motor activity. Monitoring Parameters Monitor CV and resp vital signs, LFTs and careful ECG observation.
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Adverse Reactions
Arrhythmia, bradycardia, arterial spasms, CV collapse, oedema, flushing, heart block, hypotension, sinus node suppression, agitation, anxiety, coma, confusion, drowsiness, hallucinations, euphoria, headache, hyperaesthesia, hypoaesthesia, lightheadedness, lethargy, nervousness, psychosis, seizure, slurred speech, unconsciousness, somnolence, nausea, vomiting, metallic taste, tinnitus, disorientation, dizziness, paraesthesia, resp depression and convulsions. Patch: Bruising, depigmentation, petechiae, irritation. Ophth: Conjunctival hyperaemia, corneal epithelial changes, diplopia, visual changes.
Potentially Fatal: Hypotension and bradycardia leading to cardiac arrest. |
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Drug Interactions
May increase serum levels w/ cimetidine and propranolol. Increased risk of cardiac depression w/ β-blockers and other antiarrhythmics. Additive cardiac effects w/ IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased w/ long-term use of phenytoin and other enzyme-inducers.
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CIMS Class
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ATC Classification
R02AD02 - lidocaine ; Belongs to the class of local anesthetics used in throat preparations.
C01BB01 - lidocaine ; Belongs to class Ib antiarrhythmics. D04AB01 - lidocaine ; Belongs to the class of topical anesthetics used in the treatment of pruritus. N01BB02 - lidocaine ; Belongs to the class of amides. Used as local anesthetics. S01HA07 - lidocaine ; Belongs to the class of local ophthalmologic anesthetics. C05AD01 - lidocaine ; Belongs to the class of local anesthetics. Used in the topical treatment of hemorrhoids and anal fissures. S02DA01 - lidocaine ; Belongs to the class of analgesic and anesthetic agents used as otologicals. |
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