Losartan + hydrochlorothiazide


Generic Medicine Info
Contraindications
Hypersensitivity to losartan, hydrochlorothiazide or sulfonamide-derived drugs. Anuria, intravascular volume depletion. Pregnancy. Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min).
Special Precautions
Patient with significant aortic/mitral stenosis, prediabetes or diabetes mellitus, history of gout, SLE, moderate or high cholesterol concentrations, unstented unilateral/bilateral renal artery stenosis, or those undergoing surgery. Black patients. Hepatic and severe renal impairment. Lactation. Monitoring Parameters Monitor blood pressure, serum electrolytes and renal function at baseline and periodically. Observe for clinical signs of fluid or electrolyte imbalance.
Adverse Reactions
Significant: Hypersensitivity reactions, electrolyte disturbance (e.g. hyperkalaemia, hypokalaemia, hypochloraemic alkalosis, hyponatraemia, hypomagnesaemia), symptomatic hypotension, acute transient myopia, acute angle-closure glaucoma, exacerbation of SLE, photosensitivity, renal function deterioration. Rarely, angioedema. Blood and lymphatic system disorders: Anaemia, agranulocytosis, leucopenia. Cardiac disorders: Tachycardia, palpitations, chest pain. Eye disorders: Transient blurred vision, xanthopsia. Gastrointestinal disorders: Abdominal pain, nausea, vomiting, dyspepsia, gastric irritation, cramping, pancreatitis, sialoadenitis, dysgeusia. General disorders and administration site conditions: Asthenia, malaise, weakness. Hepatobiliary disorders: Jaundice. Investigations: Liver function abnormalities. Metabolism and nutrition disorders: Anorexia, hyperglycaemia, hyperuricaemia. Musculoskeletal and connective tissue disorders: Back pain, leg pain, myalgia, muscle cramps or spasms. Nervous system disorders: Dizziness, headache, paraesthesia, migraine. Psychiatric disorders: Restlessness, insomnia. Renal and urinary disorders: Glycosuria, renal dysfunction, interstitial nephritis. Reproductive system and breast disorders: Impotence, erectile dysfunction. Respiratory, thoracic and mediastinal disorders: Nasal congestion, cough, upper respiratory infection, sinusitis, sinus disorder. Skin and subcutaneous tissue disorders: Rash, urticaria, pruritus, purpura. Vascular disorders: Orthostatic effects (dose-related), necrotising angiitis (vasculitis, cutaneous vasculitis).
Drug Interactions
May increase serum K with K-sparing diuretics (e.g. spironolactone, triamterene, amiloride), K supplements, K-containing salt substitutes. May increase serum lithium concentration and toxicity.
CIMS Class
Angiotensin II Antagonists / Diuretics
ATC Classification
C03AA03 - hydrochlorothiazide ; Belongs to the class of low-ceiling thiazide diuretics.
C09CA01 - losartan ; Belongs to the class of angiotensin II antagonists. Used in the treatment of cardiovascular disease.
Disclaimer: This information is independently developed by CIMS based on losartan + hydrochlorothiazide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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