Losartan + ramipril


Generic Medicine Info
Contraindications
Hypersensitivity, history of angioedema, bilateral renal stenosis, high-dose diuretic therapy, salt depleted states, renal impairment, pregnancy
Special Precautions
Patients on diuretic, renal impairment, heart failure and hereditary edema, serum K conc should be monitored in elderly and patients with renal stenosis and lactation.
Adverse Reactions
First-dose hypotension, angioedema, hyperkalaemia, dyspepsia, muscle cramp, myalgia, dizziness, insomnia, nasal congestion, cough, upper resp infection, sinusitis, asthenia, oedema, abdominal pain, chest pain, nausea, headache, pharyngitis, superficial peeling of palms and haemolysis, renal impairment, pancytopaenia, haemolytic anaemia, thrombocytopaenia, increase in BUN and serum creatinine, angioneurotic oedema, cough, arthralgia, fever, impotence, increased sweating, malaise, wt gain, rash.
Drug Interactions
Concomitant use of potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements, or salt substitutes containing K may lead to increase in serum potassium. Cimetidine may increase AUC of losartan, phenobarbital may reduce the AUC of losartan and that of its active metabolite. Co-administration with diuretics can cause hypotension. Serum lithium level is increased when lithium is co-administered with ramipril.
ATC Classification
C09AA05 - ramipril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
C09CA01 - losartan ; Belongs to the class of angiotensin II antagonists. Used in the treatment of cardiovascular disease.
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