Loteprednol


Full Generic Medicine Info
Dosage/Direction for Use

Ophthalmic
Allergic and inflammatory conditions of the eye
Adult: As 0.5% susp: Instill 1-2 drops onto affected eye(s) 4 times daily.

Ophthalmic
Seasonal allergic conjunctivitis
Adult: As 0.2% susp: Instill 1 drop onto affected eye(s) 4 times daily.

Ophthalmic
Postoperative ocular inflammation
Adult: As 0.5% susp: Instill 1-2 drops onto affected eye(s) 4 times daily, beginning 24 hr after surgery and continuing through the 1st 14 days of post-op period. As 0.5% oint: Apply approx ½ inch ribbon into the conjunctival sac onto the affected eye(s) 4 times daily, beginning 24 hr after surgery and continuing through the 1st 14 days of post-op period. As 0.5% gel: Instill 1-2 drops to the affected eye(s) 4 times daily, beginning 24 hr after surgery and continuing through the 1st 14 days of post-op period.
Contraindications
Ocular viral (e.g epithelial herpes simplex keratitis), fungal, and mycobacterial infection.
Special Precautions
Patient w/ glaucoma, history of ocular herpes simplex. Pregnancy and lactation. Patient Counselling Remove contact lenses prior to ophth admin and reinsert after 15 min. This drug may cause transient effects on vision, if affected, do not drive or operate machinery. Monitoring Parameters Monitor intraocular pressure (if used for >10 days); signs and symptoms of other infections (e.g. fungal).
Adverse Reactions
Significant: Increased ocular pressure, optic nerve injury, visual acuity and field of vision defect, posterior subcapsular cataract formation, corneal or scleral thinning, delayed wound healing, secondary ocular infection (e.g. bacterial, viral, fungal infection). Nervous: Headache. Resp: Pharyngitis, rhinitis. Ophthalmologic: Application site burning, foreign body sensation, chemosis, anterior chamber inflammation, blurred vision, epiphora, eye discharge, photophobia, visual disturbance, xerophthalmia, conjunctival hyperaemia, corneal oedema, eye pain, blepharitis, conjunctivitis, corneal changes, eye irritation, keratoconjunctivitis, uveitis, conjunctival papillae. Dermatologic: Pruritus.
Drug Interactions
May increase the risk of intraocular pressure w/ cycloplegics and other ocular hypotensive agents.
Action
Loteprednol is a corticosteroid w/ a glucocorticoid activity. It is highly lipid soluble which enhances cell penetration to induce the production of lipocortin protein that modulates the activity of prostaglandin and leukotrienes resulting in the inhibition of inflammatory response.
Onset: W/in 2 hr.
Metabolism: Undergoes extensive metabolism into inactive carboxylic acid metabolite.
Storage
Ophthalmic: Store at 15-25°C. Do not freeze.
CIMS Class
Disclaimer: This information is independently developed by CIMS based on loteprednol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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