Macrogol

Oral
Constipation
Adult: As macrogol 4000 powd: 10-20 g once daily. As macrogol 3350 powd: Initially, 17 g once daily, may be increased to bid depending on the response. Max treatment duration: 1 wk.
Child: As macrogol 4000 powd: ≥8 yr Initially, 10 g every other day, may be increased up to 20 g once daily. Max treatment duration: 3 mth. As macrogol 3350 powd: 4-5 yr Initially, 8.5 g once daily, may be increased up to a max of 17 g once daily according to response. 6-12 yr 17 g once daily. May be increased or decreased according to response. Max: 25.5 g daily. ≥12 yr Same as adult dose. Max treatment duration: 3 mth.

GI disorders (e.g. ileus, intestinal obstruction, ulcerative colitis, toxic megacolon, Crohn's disease, digestive perforation, painful abdominal syndrome).

Patient w/ CV disease e.g. CHF, ascitic conditions. Renal impairment. Childn. Pregnancy and lactation. Monitoring Parameters Assess for symptoms of bowel obstruction prior to treatment.

Significant: Fluid and electrolyte imbalance, hypersensitivity reactions (e.g rash, urticaria, oedema). GI: Nausea, vomiting, diarrhoea, anal irritation, bloating, abdominal distention, cramps, pain, urgency to defecate, fecal incontinence.

Symptoms: Diarrhoea, vomiting, abdominal pain, fluid and electrolyte imbalance. Management: Supportive therapy to correct fluid and electrolyte disturbance.

Macrogols or polyethylene glycol (PEG) are long linear polymers w/ osmotic activity. It binds water molecules and retains water in the stool, thus increasing the vol of intestinal fluids causing laxative effect.
Onset: W/in 1 hr.
Absorption: Poorly absorbed from the GI tract.
Excretion: Mainly via faeces (93%); urine (0.2%).

Oral: Store between 20-25°C.

Laxatives, Purgatives

A06AD15 - macrogol ; Belongs to the class of osmotically acting laxatives.