Magnesium chloride


Full Prescribing Info
Dosage/Direction for Use

Oral
Dietary supplementation
Adult: Adjust according to individual requirement. RDA (elemental magnesium): 19-30 yr: Female: 310 mg/day, pregnant female: 350 mg/day, male: 400 mg/day. ≥31 yr: Female: 320 mg/day, pregnant female: 360 mg/day, male: 420 mg/day.

Intravenous

Hypomagnesaemia
Adult: 4 g of Magnesium Chloride in 250 mL of 5% Dextrose inj given via IV infusion (Max rate: 3 mL/min). Monitor serum magnesium to guide subsequent dosage. Usual dosage range: 1-40 g Magnesium Chloride daily.
Contraindications
Intravenous: Patients with renal impairment, marked myocardial disease, and comatose condition.
Special Precautions
Risk of hypermagnesaemia in patients with renal impairment. Caution in myasthenia gravis, pregnancy. Oral: Take with food to reduce stomach upset and diarrhoea. Intravenous: Administer cautiously if sweating and flushing occurs. Monitor serum magnesium concentrations, respiratory rate, blood pressure, deep tendon reflex and renal function.
Adverse Reactions
Oral: Watery diarrhoea, GI irritation. Intravenous: Nausea, vomiting, flushing, thirst, hypotension.
Potentially Fatal: Potentially Hazardous: Intravenous: Hypermagnesaemia may lead to respiratory depression, loss of deep tendon reflexes and cardiac arrest.
Overdosage
Symptoms of hypermagnesaemia: Respiratory depression and loss of deep tendon reflexes due to neuromuscular blockade; nausea, vomiting, flushing, hypotension, drowsiness, bradycardia and muscle weakness. Treatment: In patients with normal renal function, IV fluids or furosemide may be given to promote Magnesium excretion. In patients with symptomatic hypermagnesaemia, slow IV inj of calcium gluconate can be used to antagonise the cardiac and neuromuscular effects of Magnesium.
Drug Interactions
Oral magnesium salts may decrease absorption of bisphosphonates, quinolone antibiotics and tetracycline derivatives; admin should be separated apart if concomitant use is required. Magnesium-containing products may reduce absorption of eltrombopag by 70%; separate admin by at least 4 hr. Calcitriol may increase serum concentrations of Magnesium salts. Magnesium salts may decrease serum concentrations of mycophenolate if used concurrently; monitor for reduced effects of mycophenolate. Concomitant use of trientine and magnesium salt may reduce serum concentrations of both agents.
Action
Magnesium is essential to many enzymatic reactions in the body, acting as a cofactor in protein synthesis and carbohydrate metabolism. 8.36 g of Magnesium chloride (hexahydrate) is equivalent to about 1 g of magnesium. Each g of magnesium chloride (hexahydrate) represents about 4.9 mmol of magnesium and 9.8 mmol of chloride.
Absorption: Oral: About one-third is absorbed from the small intestine. The fraction of magnesium absorbed is inversely proportional to amount ingested.
Distribution: Plasma protein binding: About 25-30%. Magnesium crosses the placenta.
Excretion: Parenteral magnesium salts: Excreted mainly in urine. Oral magnesium salts: Via urine (absorbed fraction); faeces (unabsorbed fraction).
Storage
Intravenous: Oral: Store at room temperature, away from light and moisture. Intravenous inj: Prior to reconstitution, store at 15-30°C (59-86°F). Oral: Oral: Store at room temperature, away from light and moisture. Intravenous inj: Prior to reconstitution, store at 15-30°C (59-86°F).
CIMS Class
ATC Classification
B05XA11 - magnesium chloride ; Belongs to the class of electrolyte solutions used in I.V. solutions.
A12CC01 - magnesium chloride ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements.
Disclaimer: This information is independently developed by CIMS based on magnesium chloride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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