Magnesium hydroxide


Full Generic Medicine Info
Dosage/Direction for Use

Oral
Constipation
Adult: For relief of occasional cases: As 400 mg/5 mL or 1,200 mg/15 mL suspension: 30-60 mL. As 2,400 mg/10 mL: 15-30 mL. All doses may be taken once daily (preferably at bedtime) or in divided doses, or as directed. As 800 mg/5 mL suspension: 10-20 mL once daily (preferably at bedtime). Drink a full glass of water with each dose. As 1,325 mg/5 mL paste concentrated suspension: 25-50 mL diluted in a glass of water to be taken at bedtime. Dosage recommendations may vary among countries and individual products (refer to specific product guideline).
Child: For relief of occasional cases: 2-<6 years As 400 mg/5 mL or 1,200 mg/15 mL suspension; 400 mg chewable tablet: 400-1,200 mg daily as single or in divided doses (Max: 1,200 mg/day). As 800 mg/5 mL suspension: 800 mg once daily (preferably at bedtime) or as directed. 6-<12 years As 400 mg/5 mL or 1,200 mg/15 mL suspension; 400 mg chewable tablet: 1,200-2,400 mg daily as single or in divided doses (Max: 2,400 mg/day). As 800 mg/5 mL suspension: 800-1,600 mg once daily (preferably at bedtime). Drink a full glass of water with each dose. ≥12 years Same as adult dose. Dosage recommendations may vary among countries and individual products (refer to specific product guideline).
Renal impairment: Severe renal failure: Contraindicated.

Oral
Hyperacidity
Adult: For the relief of heartburn, indigestion or upset stomach: As 400 mg/5 mL suspension: 5-15 mL up to 4 times daily, or as directed. As 2,400 mg/10 mL suspension: 5 mL. Max: 20 mL in 24 hours. Doses may be taken with water. As 1,325 mg/5 mL paste concentrated suspension: 5-10 mL diluted in small amount of water, as necessary. Dosage recommendations may vary among countries and individual products (refer to specific product guideline).
Child: ≥12 years Same as adult dose.
Renal impairment: Severe renal failure: Contraindicated.
Administration
Susp: Should be taken on an empty stomach. Take 1 hr after meals & at bedtime.
Contraindications
Acute gastrointestinal conditions; severe renal failure.
Special Precautions
Patients with myasthenia gravis or neuromuscular disease, sudden change in bowel habits (which persists for >2 weeks), Mg-restricted diet; stomach pain, nausea or vomiting. Debilitated patients. Renal and hepatic impairment. Children and elderly. Pregnancy and lactation.
Adverse Reactions
Significant: Rarely, hypermagnesaemia (particularly in patients with renal impairment). Gastrointestinal disorders: Abdominal pain, diarrhoea (dose-dependent), colic.
Overdosage
Symptoms: Watery diarrhoea, gastrointestinal irritation; rarely, hypermagnesaemia which includes symptoms such as nausea, vomiting, thirst, flushing, drowsiness, hypotension, confusion, loss of tendon reflexes, muscle weakness, respiratory depression, cardiac arrhythmias, cardiac arrest and coma. Management: Administer Ca gluconate 10% 10-20 mL via IV to counteract respiratory depression or heart block. May give adequate fluids to patients with normal renal function to aid removal of Mg in the body. May perform haemodialysis in patients with renal impairment or severe hypermagnesaemia.
Drug Interactions
May decrease absorption of certain antibiotics (e.g. cefpodoxime, tetracyclines, quinolones), antifungals (e.g. itraconazole), antivirals (e.g. atazanavir, rilpivirine), fexofenadine, bisphosphonates (e.g. alendronic acid, ibandronic acid), corticosteroids (e.g. dexamethasone, deflazacort), antiepileptics (e.g. gabapentin, phenytoin), certain antipsychotics (e.g. sulpiride, chlorpromazine), ACE inhibitors (e.g. captopril), rosuvastatin, chloroquine, hydroxychloroquine, proguanil, digoxin, dipyridamole, levothyroxine, mycophenolate, iron preparations, nilotinib, and penicillamine. May increase absorption of ibuprofen. May decrease the excretion of quinidine. May enhance the adverse or toxic effect, particularly metabolic alkalosis, of sodium polystyrene sulfonate. Excretion of salicylates may be increased.
Action
Magnesium hydroxide stimulates bowel movement by retaining fluid in the intestinal lumen which distends the colon, thus increasing peristalsis. It also neutralises stomach acid by reacting with hydrochloric acid in the stomach to form Mg chloride.
Onset: Bowel movement: 30 minutes to 6 hours.
Absorption: Mg: Poorly absorbed from the small intestine (approx 30%).
Distribution: Mg: Crosses the placenta; enters breast milk (small amounts).
Excretion: Mainly via urine (up to 30% as absorbed Mg ions); faeces (as unabsorbed drug).
Storage
Oral: Store below 25°C. Do not freeze.
CIMS Class
Antacids, Antireflux Agents & Antiulcerants / Laxatives, Purgatives
ATC Classification
G04BX01 - magnesium hydroxide ; Belongs to the class of other urologicals.
A02AA04 - magnesium hydroxide ; Belongs to the class of magnesium-containing antacids.
Disclaimer: This information is independently developed by CIMS based on magnesium hydroxide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
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