Magnesium sulfate


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Constipation 5-10 g in 250 mL water. Mild hypomagnesaemia 3 g 6 hrly for 4 doses. IV Hypomagnesaemia Symptomatic deficiency: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr if needed. Severe: 1-2 g/hr for 3-6 hr, then 0.5-1 g/hr as needed to correct deficiency. Torsades de pointes W/ pulses: Loading dose: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr as needed. Pulseless: 1-2 g over 5-20 mins. Barium poisoning 1-2 g. Cerebral oedema 2.5 g. Eclampsia Loading dose: 4-5 g over 10-15 mins, followed by either a continuous infusion of 1 g/hr or deep IM doses of 4-5 g into alternate buttocks 4 hrly. If seizure recurs, an additional IV dose of 2-4 g may be given. Not to exceed 30-40 g/24 hr. IM Hypomagnesaemia Mild deficiency: 1 g 6 hrly for 4 doses. Severe deficiency: Up to 250 mg/kg w/in 4 hr. Topical Boils and carbuncles Apply as a paste under dressing.
Contraindications
Parenteral: Heart block, severe renal impairment, myocardial damage.
Special Precautions
Renal impairment, myasthaenia gravis, digitalised patients; pregnancy. Monitor serum-magnesium concentrations.
Adverse Reactions
Oral: GI irritation, watery diarrhoea. Parenteral: Hypermagnesaemia characterised by nausea, vomiting, flushing, thirst, hypotension, drowsiness, confusion, slurred speech, double vision, bradycardia, muscle weakness. Hypocalcaemia; paralytic ileus.
Drug Interactions
Oral: Decreases absorption of tetracyclines and biphosphonates. Additive neuromuscular blocking effects with aminoglycosides, digitalis glycosides. Additive effects with nifedipine and CNS depressants.
ATC Classification
A12CC02 - magnesium sulfate ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements.
A06AD04 - magnesium sulfate ; Belongs to the class of osmotically acting laxatives.
B05XA05 - magnesium sulfate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
V04CC02 - magnesium sulfate ; Belongs to the class of diagnostic agents used to test for bile duct patency.
D11AX05 - magnesium sulfate ; Belongs to the class of other dermatologicals.
Disclaimer: This information is independently developed by CIMS based on magnesium sulfate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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