Magnesium sulfate


Generic Medicine Info
Contraindications
Oral: Acute gastrointestinal conditions. IV/IM: Heart block, myocardial damage, hepatic encephalopathy, hepatic failure, renal failure.
Special Precautions
Patient with myasthenia gravis or other neuromuscular disease. Debilitated patients. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters IV: Monitor vital signs, deep tendon reflexes; magnesium concentrations if frequent or prolonged dosing; renal function; ECG monitoring. Obstetrics: Monitor patient status, vital signs, oxygen saturation, respiration, deep tendon reflexes, level of consciousness, foetal heart rate, maternal uterine activity, renal function. Monitor magnesium concentrations every 4 hours in patients with renal dysfunction.
Adverse Reactions
Significant: Hypermagnesaemia. Gastrointestinal disorders: Gastrointestinal discomfort, diarrhoea. Metabolism and nutrition disorders: Hypocalcaemia, hypophosphataemia, hypertonic dehydration.
Potentially Fatal: Magnesium toxicity leading to CV arrest and/or respiratory paralysis (parenteral).
Drug Interactions
May potentiate the effects of tubocurarine. Increased risk of cardiopulmonary events with calcium channel blockers and diuretics. May cause profound hypotension with nifedipine. Reduced efficacy with calcium salts. May interfere with the absorption of ACE inhibitors (e.g. captopril, enalapril, fosinopril), antibacterials and antifungals (e.g. azithromycin, cefaclor, cefpodoxime, isoniazid, itraconazole, ketoconazole, methenamine, tetracyclines, rifampicin, quinolone antibacterials), antivirals (atazanavir, tipranavir), antihistamines (fexofenadine), bisphosphonates; corticosteroids (deflazacort), dipyridamole, antiepileptics (e.g. gabapentin, phenytoin), lansoprazole, levothyroxine, mycophenolate, rosuvastatin, antipsychotics (e.g. sulpiride, phenothiazines), chloroquine, hydroxychloroquine, penicillamine, and digoxin if given concomitantly. May reduce absorption of eltrombopag. May reduce plasma concentration of ulipristal, erlotinib.
CIMS Class
Anticonvulsants / Electrolytes / Laxatives, Purgatives
ATC Classification
B05XA05 - magnesium sulfate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
V04CC02 - magnesium sulfate ; Belongs to the class of diagnostic agents used to test for bile duct patency.
D11AX05 - magnesium sulfate ; Belongs to the class of other dermatologicals.
A12CC02 - magnesium sulfate ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements.
A06AD04 - magnesium sulfate ; Belongs to the class of osmotically acting laxatives.
Disclaimer: This information is independently developed by CIMS based on magnesium sulfate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 CIMS. All rights reserved. Powered by CIMSAsia.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in