Magnesium sulfate

Oral: Acute gastrointestinal conditions. IV/IM: Heart block, myocardial damage, hepatic encephalopathy, hepatic failure, renal failure.

Patient with myasthenia gravis or other neuromuscular disease. Debilitated patients. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters IV: Monitor vital signs, deep tendon reflexes; magnesium concentrations if frequent or prolonged dosing; renal function; ECG monitoring. Obstetrics: Monitor patient status, vital signs, oxygen saturation, respiration, deep tendon reflexes, level of consciousness, foetal heart rate, maternal uterine activity, renal function. Monitor magnesium concentrations every 4 hours in patients with renal dysfunction.

Significant: Hypermagnesaemia. Gastrointestinal disorders: Gastrointestinal discomfort, diarrhoea. Metabolism and nutrition disorders: Hypocalcaemia, hypophosphataemia, hypertonic dehydration.
Potentially Fatal: Magnesium toxicity leading to CV arrest and/or respiratory paralysis (parenteral).

May potentiate the effects of tubocurarine. Increased risk of cardiopulmonary events with calcium channel blockers and diuretics. May cause profound hypotension with nifedipine. Reduced efficacy with calcium salts. May interfere with the absorption of ACE inhibitors (e.g. captopril, enalapril, fosinopril), antibacterials and antifungals (e.g. azithromycin, cefaclor, cefpodoxime, isoniazid, itraconazole, ketoconazole, methenamine, tetracyclines, rifampicin, quinolone antibacterials), antivirals (atazanavir, tipranavir), antihistamines (fexofenadine), bisphosphonates; corticosteroids (deflazacort), dipyridamole, antiepileptics (e.g. gabapentin, phenytoin), lansoprazole, levothyroxine, mycophenolate, rosuvastatin, antipsychotics (e.g. sulpiride, phenothiazines), chloroquine, hydroxychloroquine, penicillamine, and digoxin if given concomitantly. May reduce absorption of eltrombopag. May reduce plasma concentration of ulipristal, erlotinib.

Anticonvulsants / Electrolytes / Laxatives, Purgatives

B05XA05 - magnesium sulfate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
V04CC02 - magnesium sulfate ; Belongs to the class of diagnostic agents used to test for bile duct patency.
D11AX05 - magnesium sulfate ; Belongs to the class of other dermatologicals.
A12CC02 - magnesium sulfate ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements.
A06AD04 - magnesium sulfate ; Belongs to the class of osmotically acting laxatives.