Magnesium sulfate

Listed in Dosage.

Adult: PO Constipation 5-10 g in 250 mL water. Mild hypomagnesaemia 3 g 6 hrly for 4 doses. IV Hypomagnesaemia Symptomatic deficiency: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr if needed. Severe: 1-2 g/hr for 3-6 hr, then 0.5-1 g/hr as needed to correct deficiency. Torsades de pointes W/ pulses: Loading dose: 1-2 g over 5-60 mins, then maintain at 0.5-1 g/hr as needed. Pulseless: 1-2 g over 5-20 mins. Barium poisoning 1-2 g. Cerebral oedema 2.5 g. Eclampsia Loading dose: 4-5 g over 10-15 mins, followed by either a continuous infusion of 1 g/hr or deep IM doses of 4-5 g into alternate buttocks 4 hrly. If seizure recurs, an additional IV dose of 2-4 g may be given. Not to exceed 30-40 g/24 hr. IM Hypomagnesaemia Mild deficiency: 1 g 6 hrly for 4 doses. Severe deficiency: Up to 250 mg/kg w/in 4 hr. Topical Boils and carbuncles Apply as a paste under dressing.

Parenteral: Heart block, severe renal impairment, myocardial damage.

Renal impairment, myasthaenia gravis, digitalised patients; pregnancy. Monitor serum-magnesium concentrations.

Oral: GI irritation, watery diarrhoea. Parenteral: Hypermagnesaemia characterised by nausea, vomiting, flushing, thirst, hypotension, drowsiness, confusion, slurred speech, double vision, bradycardia, muscle weakness. Hypocalcaemia; paralytic ileus.

Oral: Decreases absorption of tetracyclines and biphosphonates. Additive neuromuscular blocking effects with aminoglycosides, digitalis glycosides. Additive effects with nifedipine and CNS depressants.

Other Dermatologicals / Electrolytes / Anticonvulsants / Laxatives, Purgatives

A12CC02 - magnesium sulfate ; Belongs to the class of magnesium-containing preparations. Used as dietary supplements.
A06AD04 - magnesium sulfate ; Belongs to the class of osmotically acting laxatives.
B05XA05 - magnesium sulfate ; Belongs to the class of electrolyte solutions used in I.V. solutions.
V04CC02 - magnesium sulfate ; Belongs to the class of diagnostic agents used to test for bile duct patency.
D11AX05 - magnesium sulfate ; Belongs to the class of other dermatologicals.