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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Ascariasis; Hookworm infections; Trichuriasis 100 mg bid for 3 consecutive days or 500 mg as single dose. Enterobiasis 100 mg as single dose; may repeat if necessary 2-3 weeks after initial treatment.
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Administration
May be taken with or without food.
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Contraindications
Hypersensitivity. Pregnancy.
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Special Precautions
Prolonged use. Hepatic impairment. Lactation. Children < 2 years. Monitoring Parameters Monitor blood count on higher doses and prolonged duration. Periodic assessment of haematologic, hepatic and renal function. Check for helminth ova in faeces within 3-4 weeks following initial therapy.
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Adverse Reactions
Significant: Bone marrow suppression e.g. agranulocytosis, neutropenia.
Gastrointestinal disorders: Diarrhoea, flatulence, abdominal pain, anorexia, nausea, vomiting.
Hepatobiliary disorders: Hepatitis, abnormal liver tests.
Nervous system disorder: Convulsion, headache, dizziness.
Skin and subcutaneous tissue disorders: Exanthema, angioedema, urticaria, alopecia, rash.
Potentially Fatal: Toxic epidermal necrolysis, Stevens-Johnson syndrome. |
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Drug Interactions
Increased plasma concentration with cimetidine. Decreased serum concentration with carbamazepine, fosphenytoin, phenytoin.
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CIMS Class
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ATC Classification
P02CA01 - mebendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
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