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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Peripheral neuropathies; Megaloblastic anaemia caused by vitamin B12 deficiency 500 mcg tid. IV/IM Peripheral neuropathies 500 mcg 3 times weekly. IV/IM Megaloblastic anaemia caused by vitamin B12 deficiency 500 mcg 3 times weekly for 2 months. Maintenance therapy: 500 mcg every 1-3 months.
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Administration
May be taken with or without food.
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Special Precautions
Pregnancy and lactation. Monitoring Parameters Monitor serum K and vitamin B12 levels; haematocrit and reticulocyte counts.
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Adverse Reactions
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain.
General disorders and administration site conditions: Hot sensation, diaphoresis, pain/induration (IM).
Immune system disorder: Rarely, hypersensitivity reaction e.g. rash, dyspnoea.
Metabolism and nutrition disorders: Anorexia.
Nervous system disorders: Headache.
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Drug Interactions
Decreased absorption with aminosalicylic acid, chloramphenicol, colchicine, histamine-2 antagonists, neomycin and proton pump inhibitors (e.g. omeprazole). Decreased serum concentrations with oral contraceptives. Impaired therapeutic response with large and continuous doses of folic acid.
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ATC Classification
B03BA05 - mecobalamin ; Belongs to the class of vitamin B12 (cyanocobalamin and analogues). Used in the treatment of anemia.
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