Meglumine gadopentetate


Full Prescribing Info
Dosage/Direction for Use

Intravenous
As a contrast media in magnetic resonance imaging
Adult: As a 0.5 mmol/ml solution: 0.1 mmol/kg at a rate no faster than 10 ml per 15 seconds. For cranial and spinal imaging, a further dose of 0.1 mmol/kg (up to 0.2 mmol/kg) may be given within 30 min if necessary. For whole body imaging, a dose of 0.2 mmol/kg may be needed in some cases to produce adequate contrast and, up to 0.3 mmol/kg may be used in some cases.
Child: As a 0.5 mmol/ml solution: 0.1 mmol/kg at a rate no faster than 10 ml per 15 seconds. For cranial and spinal imaging, a further dose of 0.1 mmol/kg may be given within 30 min if necessary. For whole body imaging in children >2 yr, a dose of 0.2 mmol/kg may be needed in some cases to produce adequate contrast.

Intra-arterial

As a contrast media in magnetic resonance imaging
Adult: As a 0.002 mmol/ml solution: Dose depends on the joint being imaged; the usual range is from 1-20 ml.
Special Precautions
Patients with severe renal impairment, epilepsy, hypotension, sickle cell anaemia, children <2 yr, a history of hypersensitivity, asthma or other allergic respiratory disorders. Care should be taken to avoid extravasation. Caution when used in patients with conditions predisposed to development of thrombotic syndromes. Caution when interpreting a contrast enhanced scan in the absence of a companion unenhanced MRI.
Adverse Reactions
Headache, nausea, vomiting, paraesthesias, dizziness and localised pain. Transient sensations of heat or cold or taste disturbances on inj of gadopentetate or other gadolinium chelates. Rarely, convulsions, hypotension, allergic or anaphylactoid reactions and shock may occur.
Potentially Fatal: Severe anaphylactic reactions.
Lab Interference
May interfere with tests of serum iron or bilirubin concentrations.
Action
Meglumine gadopentetate is a paramagnetic agent that is used as a contrast medium in magnetic resonance imaging of cranial and spinal structures, the whole body and may also be used for evaluation of renal function. It is given by intra-articular injection for arthrography and has been used orally and rectally in imaging of the GI tract.
Storage
Intra-arterial: 15-30°C Intravenous: 15-30°C
CIMS Class
ATC Classification
V08CA01 - gadopentetic acid ; Belongs to the class of paramagnetic agents used as magnetic resonance imaging contrast media.
Disclaimer: This information is independently developed by CIMS based on meglumine gadopentetate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 CIMS. All rights reserved. Powered by CIMSAsia.com
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